ABT-670
ABT-670 structure
|
Common Name | ABT-670 | ||
|---|---|---|---|---|
| CAS Number | 630119-43-6 | Molecular Weight | 325.40500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H23N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ABT-670ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively. |
| Name | 3-methyl-N-[[4-(1-oxidopyridin-1-ium-2-yl)piperidin-1-yl]methyl]benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively. |
|---|---|
| Related Catalog | |
| Target |
EC50: 89 nM (Human D4), 160 nM (Ferret D4), 93 nM (Rat D4)[1] |
| In Vitro | ABT-670 is a selective D4 agonist, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively[1]. |
| In Vivo | ABT-670 (0.1 μmol/kg) robustly induces a high (75%) incidence of erections in male rats. ABT-670 exhibits excellent oral bioavailability in rat, dog, and monkey (68%, 85%, and 91%, respectively) with comparable efficacy, safety, and tolerability[1]. |
| References |
| Molecular Formula | C19H23N3O2 |
|---|---|
| Molecular Weight | 325.40500 |
| Exact Mass | 325.17900 |
| PSA | 61.29000 |
| LogP | 3.50310 |
| Storage condition | 2-8℃ |
|
~%
ABT-670 CAS#:630119-43-6 |
| Literature: Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q. Patent: US2003/229094 A1, 2003 ; Location in patent: Page 98 ; US 20030229094 A1 |
|
~%
ABT-670 CAS#:630119-43-6 |
| Literature: Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
|
~%
ABT-670 CAS#:630119-43-6 |
| Literature: Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
|
~%
ABT-670 CAS#:630119-43-6 |
| Literature: Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
|
~%
ABT-670 CAS#:630119-43-6 |
| Literature: Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
|
~%
ABT-670 CAS#:630119-43-6 |
| Literature: Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465 |
![3',6'-DIHYDRO-2'H-[2,4']BIPYRIDINYL-1'-CARBOXYLIC ACID TERT-BUTYL ESTER structure](https://image.chemsrc.com/caspic/009/90606-77-2.png)
![1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-carboxylic acid tert-butyl ester structure](https://image.chemsrc.com/caspic/497/279250-32-7.png)
![3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-carboxylic acid tert-butyl ester structure](https://image.chemsrc.com/caspic/238/206446-49-3.png)
| 2-(1-{[(3-methylbenzoyl)amino]methyl}-4-piperidinyl)pyridinium N-oxide |
| UNII-4L6071XH2J |
| Benzamide,3-methyl-N-[[4-(1-oxido-2-pyridinyl)-1-piperidinyl]methyl] |
| ABT-670 |