Benzo[b]thiophene-2-carboxamide,N-phenyl-

Modify Date: 2025-08-22 18:12:51

Benzo[b]thiophene-2-carboxamide,N-phenyl- Structure
Benzo[b]thiophene-2-carboxamide,N-phenyl- structure
 Common Name Benzo[b]thiophene-2-carboxamide,N-phenyl-
CAS Number 6314-40-5 Molecular Weight 253.31900
Density 1.32g/cm3 Boiling Point 346.2ºC at 760 mmHg
Molecular Formula C15H11NOS Melting Point N/A
MSDS N/A Flash Point 163.1ºC

 Use of Benzo[b]thiophene-2-carboxamide,N-phenyl-


Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

 Names

Name N-phenyl-1-benzothiophene-2-carboxamide
Synonym More Synonyms

  Biological Activity

Description Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].
Related Catalog
Target

Aβ42 aggregation[1]

References

[1]. Zhao Y et al. Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity. ACS Chem Neurosci. 2023 Nov 16.  

 Chemical & Physical Properties

Density 1.32g/cm3
Boiling Point 346.2ºC at 760 mmHg
Molecular Formula C15H11NOS
Molecular Weight 253.31900
Flash Point 163.1ºC
Exact Mass 253.05600
PSA 57.34000
LogP 4.22660
Index of Refraction 1.735
InChIKey QFWHYKVMOFOKHM-UHFFFAOYSA-N
SMILES O=C(Nc1ccccc1)c1cc2ccccc2s1

 Safety Information

HS Code 2934999090

 Synthetic Route

tnca structure

tnca

CAS#:6314-28-9

structure

CAS#:74497-02-2

~71%

Benzo[b]thiophene-2-carboxamide,N-phenyl- Structure

Benzo[b]thiophe...

CAS#:6314-40-5

Literature: Antonow, Dyeison; Marrafa, Teresa; Dawood, Irfaan; Ahmed, Tauheed; Haque, Mohammad R.; Thurston, David E.; Zinzalla, Giovanna Chemical Communications, 2010 , vol. 46, # 13 p. 2289 - 2291
BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE structure

BENZO[B]THIOPHE...

CAS#:39827-11-7

structure

CAS#:74497-02-2

~%

Benzo[b]thiophene-2-carboxamide,N-phenyl- Structure

Benzo[b]thiophe...

CAS#:6314-40-5

Literature: Goettsch; Wiese Journal of the American Pharmaceutical Association (1912-1977), 1958 , vol. 47, p. 319,320
Thianaphthene structure

Thianaphthene

CAS#:95-15-8

~%

Benzo[b]thiophene-2-carboxamide,N-phenyl- Structure

Benzo[b]thiophe...

CAS#:6314-40-5

Literature: Shirley; Cameron Journal of the American Chemical Society, 1952 , vol. 74, p. 664

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

benzo[b]thiophene-2-carboxylic acid anilide
benzothiophene-2-carboxanilide
HMS3078J06
Benzo[b]thiophen-2-carbonsaeure-anilid
Benzo[b]thiophene-2-carboxanilide
2-Benzo<b>thenoyl-anilid
N-phenylbenzo[b]thiophene-2-carboxamide
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Chemsrc provides CAS#:6314-40-5 MSDS, density, melting point, boiling point, structure, etc. Its name is Benzo[b]thiophene-2-carboxamide,N-phenyl->> amp version: Benzo[b]thiophene-2-carboxamide,N-phenyl-

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