Aspoxicillin
Modify Date: 2024-01-03 00:54:15
Aspoxicillin structure
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Common Name | Aspoxicillin | ||
|---|---|---|---|---|
| CAS Number | 63358-49-6 | Molecular Weight | 493.533 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 985.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H27N5O7S | Melting Point | 195-198° (dec) | |
| MSDS | Chinese USA | Flash Point | 549.5±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of AspoxicillinAspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes[1][2]. |
| Name | Aspoxicillin |
|---|---|
| Synonym | More Synonyms |
| Description | Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes[1][2]. |
|---|---|
| Related Catalog | |
| Target |
microbe[1] |
| In Vitro | Aspoxicillin is a semisynthetic penicillin derivative[2]Aspoxicillin induces postantibiotic effects (PAEs) against Staphylococcus aureus Smith of 1.7 h in vitro[2]. |
| In Vivo | Aspoxicillin induces PAEs against Staphylococcus aureus Smith of 5.2 h in vivo in a thigh infection model in neutropenic mice[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 985.1±65.0 °C at 760 mmHg |
| Melting Point | 195-198° (dec) |
| Molecular Formula | C21H27N5O7S |
| Molecular Weight | 493.533 |
| Flash Point | 549.5±34.3 °C |
| Exact Mass | 493.163116 |
| PSA | 215.87000 |
| LogP | -0.53 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.672 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| RTECS | MB7548000 |
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[In vitro study on efficacy of combination use of aspoxicillin and beta-lactam preparations (ceftazidime, cefmetazole and aztreonam) against bacteria isolated from abdominal infections].
Jpn. J. Antibiot. 45(7) , 763-73, (1992) An in vitro study was done to evaluate combination use of aspoxicillin (ASPC) with each of 3 beta-lactam preparations, ceftazidime (CAZ), cefmetazole (CMZ) and aztreonam (AZT). The results obtained ar... |
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[A clinical study of combined therapy of aspoxicillin and ceftazidime on intractable respiratory infections].
Jpn. J. Antibiot. 45(10) , 1282-94, (1992) Both aspoxicillin (ASPC) and ceftazidime (CAZ) were administered together to 55 patients with intractable respiratory tract infections. ASPC and CAZ were administered at daily doses of 4 g and 2 to 4 ... |
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Separation and determination of aspoxicillin in human plasma by micellar electrokinetic chromatography with direct sample injection.
J. Chromatogr. A. 515 , 245-55, (1990) Both the separation and determination of aspoxicillin in human plasma by micellar electrokinetic chromatography (MEKC) were investigated. Selectivity in the separation of seven penicillin antibiotics ... |
| glycinamide,n-methyl-d-asparaginyl-n-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-a |
| (2S,5R,6R)-6-({(2R)-2-(4-Hydroxyphenyl)-2-[(N-methyl-D-asparaginyl)amino]acetyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[(2R)-2-amino-4-(methylamino)-1,4-dioxobutyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- |
| ASPOXICILLIN 3-HYDRATE |
| n(sup4)-methyl-d-asparagininylamoxicillin |
| Aspoxicillin |
| [2S-(2a,5a,6b)]-N-Methyl-D-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-D-2-(4-hydroxyphenyl)glycinamide |
| N4-Methyl-D-asparaginylamoxicillin |
| 6-[D-2-(D-2-Amino-3-N-methylcarbamoylpropionamido)-2-p-hydroxyphenylacetamido]penicillanic Acid |
| Doyle |
| Aspoxicilin |
| (2S,5R,6R)-6-[(2R)-2-[(2R)-2-Amino-3-(methylcarbamoyl)propionamido]-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
| TA 058 |
| ASPC |