Movens

Modify Date: 2025-08-23 09:05:05

Movens Structure
Movens structure
Common Name Movens
CAS Number 6385-02-0 Molecular Weight 336.146
Density N/A Boiling Point 399.4ºC at 760 mmHg
Molecular Formula C14H10Cl2NNaO2 Melting Point 287 °C
MSDS USA Flash Point 195.3ºC

 Use of Movens


Meclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3].

 Names

Name meclofenamate sodium
Synonym More Synonyms

 Movens Biological Activity

Description Meclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3].
References

[1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.

[2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.

[3]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.

 Chemical & Physical Properties

Boiling Point 399.4ºC at 760 mmHg
Melting Point 287 °C
Molecular Formula C14H10Cl2NNaO2
Molecular Weight 336.146
Flash Point 195.3ºC
Exact Mass 335.009186
PSA 52.16000
LogP 3.48190
Water Solubility Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB2975500
CHEMICAL NAME :
Anthranilic acid, N-(2,6-dichloro-m-tolyl)-, monosodium salt
CAS REGISTRY NUMBER :
6385-02-0
LAST UPDATED :
199703
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C14-H10-Cl2-N-O2.Na
MOLECULAR WEIGHT :
318.14
WISWESSER LINE NOTATION :
OVR BMR BG FG C1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
521 mg/kg/78W-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
AJGAAR American Journal of Gastroenterology. (American College of Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21- 1954- Volume(issue)/page/year: 82,1320,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
120 mg/kg/6W
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,631,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, allergic (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 10,169,1983 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
112 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 15,46,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
261 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,665,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
324 mg/kg
SEX/DURATION :
female 15 day(s) pre-mating female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,665,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
522 mg/kg
SEX/DURATION :
female 15 day(s) pre-mating - 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,665,1985

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CB2975500
HS Code 2922499990

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles1

More Articles
Boctor, A.M., et al.

Prostaglandins Leukotrienes Med. 23 , 229, (1986)

 Synonyms

Sodium 2-[(2,6-dichloro-3-methylphenyl)amino]benzoate hydrate (1:1:1)
sodium,2-(2,6-dichloro-3-methylanilino)benzoate
Monosodium N-(2,6-dichloro-m-tolyl)anthranilate monohydrate
EINECS 228-983-3
Sodium meclophenamate
MFCD00077376
2-((2,6-Dichloro-3-methylphenyl)amino)benzoic Acid Monosodium Salt Monohydrate
Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt, hydrate (1:1:1)
Sodium meclofenamate
N-(2,6-Dichloro-m-tolyl)anthranilic Acid Monosodium Salt Monohydrate
Movens
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