meclofenamic acid

Modify Date: 2026-07-01 19:21:53

meclofenamic acid structure	Common Name	meclofenamic acid
	CAS Number	644-62-2	Molecular Weight	296.149
	Density	1.4±0.1 g/cm3	Boiling Point	399.4±42.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₁Cl₂NO₂	Melting Point	257-259ºC
	MSDS	N/A	Flash Point	195.3±27.9 °C

Use of meclofenamic acid

Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	meclofenamic acid
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3].
References	[1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8. [2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017. [3]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.

Description

References

[1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.

[2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.

[3]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.4±0.1 g/cm3
Boiling Point	399.4±42.0 °C at 760 mmHg
Melting Point	257-259ºC
Molecular Formula	C₁₄H₁₁Cl₂NO₂
Molecular Weight	296.149
Flash Point	195.3±27.9 °C
Exact Mass	295.016693
PSA	49.33000
LogP	6.67
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.663
Storage condition	Refrigerator

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB2900000

CHEMICAL NAME :: Anthranilic acid, N-(2,6-dichloro-m-tolyl)-

CAS REGISTRY NUMBER :: 644-62-2

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H11-Cl2-N-O2

MOLECULAR WEIGHT :: 296.16

WISWESSER LINE NOTATION :: QVR BMR BG FG C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 7,481,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 109 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 148,422,1965 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 239 ng/kg

SEX/DURATION :: female 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 63,365,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 200 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 38,238,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 2750 ug/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 14,451,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15 mg/kg

SEX/DURATION :: female 16 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 65,157,1982

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2922499990

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

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This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)
Source: ChEMBL
Target: Delta-type opioid receptor
External Id: CHEMBL1909180

Name: DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-A...
Source: ChEMBL
Target: Nitric oxide synthase, inducible
External Id: CHEMBL1909179

Name: DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)
Source: ChEMBL
Target: Mu-type opioid receptor
External Id: CHEMBL1909182

Name: DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)
Source: ChEMBL
Target: Kappa-type opioid receptor
External Id: CHEMBL1909181

Name: DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909184

Name: DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909183

Name: Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysi...
Source: ChEMBL
Target: Transthyretin
External Id: CHEMBL3602658

Name: DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP)
Source: ChEMBL
Target: cGMP-specific 3',5'-cyclic phosphodiesterase
External Id: CHEMBL1909186

Name: Binding affinity to TTR in human plasma assessed as protein stabilization preincubate...
Source: ChEMBL
Target: Transthyretin
External Id: CHEMBL3602659

Name: DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909185

Total 283, Current Page 1 of 29

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

meclofenamate

2-(2,6-dichloro-3-methylanilino)benzoic acid

2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid

meclofenamic acid

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of meclofenamic acid?

A: The English name of meclofenamic acid is meclofenamic acid.

Q: What is the boiling point of meclofenamic acid?

A: Boiling point of meclofenamic acid is 399.4±42.0 °C at 760 mmHg.

Q: What are the storage conditions for meclofenamic acid?

A: Storage conditions for meclofenamic acid: Refrigerator.

Q: What is the molecular formula of meclofenamic acid?

A: Molecular formula of meclofenamic acid is C14H11Cl2NO2.

Q: What English synonyms does meclofenamic acid have?

A: English synonyms of meclofenamic acid: meclofenamate, 2-(2,6-dichloro-3-methylanilino)benzoic acid, 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid, meclofenamic acid.

Q: What are the uses of meclofenamic acid?

A: Main uses of meclofenamic acid: Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3].

Q: What is the molecular weight of meclofenamic acid?

A: Molecular weight of meclofenamic acid is 296.149.

Q: What is the melting point of meclofenamic acid?

A: Melting point of meclofenamic acid is 257-259ºC.

Q: What is the polar surface area (PSA) of meclofenamic acid?

A: Polar surface area (PSA) of meclofenamic acid is 49.33000.

Q: What is the CAS number of meclofenamic acid?

A: CAS number of meclofenamic acid is 644-62-2.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Product Name: meclofenamic acid
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Meclofenamic Acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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