Bradanicline
Modify Date: 2024-01-22 18:14:16
Bradanicline structure
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Common Name | Bradanicline | ||
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| CAS Number | 639489-84-2 | Molecular Weight | 361.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BradaniclineBradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM). Bradanicline is used for the research of cognitive disorders[1][2]. |
| Name | N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide |
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| Synonym | More Synonyms |
| Description | Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM). Bradanicline is used for the research of cognitive disorders[1][2]. |
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| Related Catalog | |
| In Vitro | Bradanicline is more than a thousand-fold separation between the affinities for the α7 and α4β2 receptor subtypes and has no detectable effects on muscle or ganglionic nicotinic receptor subtypes, indicating a marked selectivity for the central nervous system over the peripheral nervous system[1]. |
| In Vivo | Bradanicline (0.1-1 mg/kg) shows efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia[2]. |
| References |
| Molecular Formula | C22H23N3O2 |
|---|---|
| Molecular Weight | 361.44 |
| Exact Mass | 361.17900 |
| PSA | 61.86000 |
| LogP | 3.77580 |
| tc-5619 |
| tc-5619-238 |