Sodium edetate

Modify Date: 2024-01-02 11:07:12

Sodium edetate Structure
Sodium edetate structure
Common Name Sodium edetate
CAS Number 64-02-8 Molecular Weight 380.17
Density 6.9 g/cm3 Boiling Point 614.2ºC at 760 mmHg
Molecular Formula C10H12N2Na4O8 Melting Point >300 °C(lit.)
MSDS Chinese Flash Point 325.2ºC

 Use of Sodium edetate


Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can also decrease the formation of disulfide bonds[1][2][3].

 Names

Name EDTA tetrasodium
Synonym More Synonyms

 Sodium edetate Biological Activity

Description Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can also decrease the formation of disulfide bonds[1][2][3].
Related Catalog
References

[1]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9.  

[2]. Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76.  

[3]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb;10(1):58-62.  

 Chemical & Physical Properties

Density 6.9 g/cm3
Boiling Point 614.2ºC at 760 mmHg
Melting Point >300 °C(lit.)
Molecular Formula C10H12N2Na4O8
Molecular Weight 380.17
Flash Point 325.2ºC
Exact Mass 380.018433
PSA 167.00000
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility H2O: 0.1 g/mL, clear, colorless

 MSDS


Section 1: Product Identification
Chemical Name:Ethylenediaminetetraacetic acid, tetrasodium salt tetrahydrate, 99+%
CAS Registry Number:64-02-8
Formula:(NaOOCH2)2NCH2CH2N(CH2COONa)2.4H2O
EINECS Number:200-573-9
Chemical Family:organic amine
Synonym:N,N'-Ethylenediaminediacetic acid tetrasodium salt, Tetrasodium EDTA

Section 2: Composition and Information on Ingredients
IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL)
Title Compound64-02-8100%no datano data

Section 3: Hazards Identification
Emergency Overview:Irritating to eyes, skin, and respiratory tract.
Primary Routes of Exposure:Eyes, Inhalation of dust.
Eye Contact:Irritating to eyes. May cause redness and pain.
Skin Contact:Mildly irritating to skin. May cause itching and redness.
Inhalation:Dust may be irritating to the nose, mucous membranes and respiratory tract.
Ingestion:No specific information is available on the physiological effects of ingestion.
Acute Health Affects:Irritating to skin, eyes and respiratory tract.
Chronic Health Affects:No information available on long-term chronic effects.
NTP:No
IARC:No
OSHA:No

SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

SECTION 5: Fire Fighting Measures
Flash Point:no data
Autoignition Temperature:none
Explosion Limits:none
Extinguishing Medium:dry chemical, carbon dioxide, water fog, or foam.
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self-contained breathing apparatus and full protective clothing.
Hazardous Combustion andIf involved in a fire this material may emit toxic organic fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

SECTION 6: Accidental Release Measures
Small spills can be mixed with vermiculite, sodium carbonate or other suitable non combustible adsorbent and
Spill and Leak Procedures:
swept up.

SECTION 7: Handling and Storage
Handling and Storage:Store in a tightly sealed container. Keep away from heat and direct sunlight.

SECTION 8: Exposure Controls and Personal Protection
Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection:Wear appropriate chemical resistant gloves and clothing.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection:No additional protection required.

SECTION 9: Physical and Chemical Properties
Color and Form:white xtl.
Molecular Weight:380.18 (452.23)
Melting Point:no data
Boiling Point:no data
Vapor Pressure:not applicable
Specific Gravity:no data
Odor:none
Solubility in Water:soluble

SECTION 10: Stability and Reactivity
Stability:air and moisture stable
Hazardous Polymerization:no hazardous polymerization
Conditions to Avoid:none
Incompatibility:oxidizing agents
Decomposition Products:carbon monoxide, carbon dioxide, organic fumes, sodium oxide, sodium hydroxide and nitrogen oxides.

SECTION 11: Toxicological Information
Administration onto the skin (rabbit); Standard Draize test: 500 mg/24H. Administration into the eye (rabbit);
RTECS Data:Standard Draize test: 1900 ug. Administration into the eye (rabbit); Standard Draize test: 100 mg/24H.
Intraperitoneal (mouse); LD50: 330 mg/kg.
Carcinogenic Effects:no data
Mutagenic Effects:no data
Tetratogenic Effects:no data

SECTION 12: Ecological Information
Ecological Information:No information available

SECTION 13: Disposal Considerations
Disposal:Dispose of according to local, state and federal regulations.

SECTION 14: Transportation
Shipping Name (CFR):Non-hazardous
Hazard Class (CFR):NA
Additional Hazard Class (CFR):NA
Packaging Group (CFR):NA
UN ID Number (CFR):NA
Shipping Name (IATA):Non-hazardous
Hazard Class (IATA):NA
Additional Hazard Class (IATA):NA
Packaging Group (IATA):NA
UN ID Number (IATA):NA

SECTION 15: Regulatory Information
TSCA:Listed in the TSCA inventory.
SARA (Title 313):Title compound not listed.
Second Ingredient:none


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AH5075000
CHEMICAL NAME :
Acetic acid, (ethylenedinitrilo)tetra-, tetrasodium salt
CAS REGISTRY NUMBER :
64-02-8
LAST UPDATED :
199710
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C10-H12-N2-O8.4Na
MOLECULAR WEIGHT :
380.20
WISWESSER LINE NOTATION :
OV1NVO&2N1VO&1VO &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,306,1972
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AAOPAF AMA Archives of Ophthalmology. (Chicago, IL) V.44(4)-63, 1950-60. For publisher information, see AROPAW. Volume(issue)/page/year: 48,681,1952
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,306,1972 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
330 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
REPMBN Revue d'Epidemiologie, Medecine Sociale et Sante Publique. (Masson Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France) V.1- 1953- Volume(issue)/page/year: 10,391,1962 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80223 No. of Facilities: 49290 (estimated) No. of Industries: 218 No. of Occupations: 128 No. of Employees: 584676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80223 No. of Facilities: 55714 (estimated) No. of Industries: 293 No. of Occupations: 186 No. of Employees: 1388281 (estimated) No. of Female Employees: 611582 (estimated)

 Safety Information

Hazard Codes Xi:Irritant;
Risk Phrases R36/38
Safety Phrases S26-S36/37-S37/39
WGK Germany 2
RTECS AH5075000
HS Code 2922499990

 Synthetic Route

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Sodium edetate Structure

Sodium edetate

CAS#:64-02-8

Literature: Moran, Edmund J.; Fournier, Eric Patent: US2004/6102 A1, 2004 ; US 20040006102 A1

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Sodium edetate Structure

Sodium edetate

CAS#:64-02-8

Literature: Esteban, M. F. Gargallo; Serrano, Vilaplana R.; Vilchez, F. Gonzalez Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1987 , vol. 43, # 8 p. 1039 - 1044

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Sodium edetate Structure

Sodium edetate

CAS#:64-02-8

Literature: DOW GLOBAL TECHNOLOGIES LLC.; MOORE, J. W., Jr.; BOOTH, Steven, T.; LEENHOUTS, Ray, O. Patent: WO2011/146582 A2, 2011 ; Location in patent: Page/Page column 10-11 ;

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Synonyms

Ethylenediaminetetraacetic acid tetrasodium salt
Tetrasodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate
Tetrasodium ethylenediaminetetraacetate
Tetrasodium salt EDTA
MFCD00012460
EINECS 200-573-9
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, tetrasodium salt
Complexone
TETRASODIUM EDTA
Nullapon
N,N'-Ethylenediaminediacetic acid tetrasodium salt
TETRACEMATE TETRASODIUM
Tetrasodium salt of EDTA
EDTA tetrasodium salt
Tetrasodium edetate
Nervanaid B
EDETIC ACID TETRASODIUM SALT
EDTA sodium
Tetrasodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
Edetate Sodium
EDTA Tetrasodium
Endrate tetrasodium
Sodium edetate
EDTA-4NA
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