Bemegride
Modify Date: 2026-07-20 21:33:33
Bemegride structure
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Common Name | Bemegride | ||
|---|---|---|---|---|
| CAS Number | 64-65-3 | Molecular Weight | 155.194 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 282.0±9.0 °C at 760 mmHg | |
| Molecular Formula | C8H13NO2 | Melting Point | 126-127 °C(lit.) | |
| MSDS | N/A | Flash Point | 125.8±18.9 °C | |
Use of BemegrideBemegride is a central nervous system stimulant and antidote for barbiturate poisoning.target: GABAA receptor Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. [1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression. [2] |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 4-ethyl-4-methylpiperidine-2,6-dione |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.target: GABAA receptor Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. [1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression. [2] |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 282.0±9.0 °C at 760 mmHg |
| Melting Point | 126-127 °C(lit.) |
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.194 |
| Flash Point | 125.8±18.9 °C |
| Exact Mass | 155.094635 |
| PSA | 46.17000 |
| LogP | 1.52 |
| Appearance of Characters | powder | white |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.449 |
| InChIKey | ORRZGUBHBVWWOP-UHFFFAOYSA-N |
| SMILES | CCC1(C)CC(=O)NC(=O)C1 |
| Storage condition | −20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | T |
|---|---|
| Risk Phrases | R23/24/25 |
| Safety Phrases | S22-S36/37/39-S45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | MA4550000 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
| HS Code | 2925190090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Bemegride CAS#:64-65-3 |
| Literature: Collection of Czechoslovak Chemical Communications, , vol. 20, p. 1227,1232 |
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Bemegride CAS#:64-65-3 |
| Literature: Journal of the American Pharmaceutical Association (1912-1977), , vol. 39, p. 451,453 |
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Bemegride CAS#:64-65-3 |
| Literature: Journal of the American Pharmaceutical Association (1912-1977), , vol. 39, p. 451,453 Farmacja Polska, , vol. 15, p. 33 |
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Bemegride CAS#:64-65-3 |
| Literature: Yakugaku Zasshi, , vol. 77, p. 118 Chem.Abstr., , p. 8748 |
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~%
Bemegride CAS#:64-65-3 |
| Literature: Journal of the Chemical Society, , vol. 99, p. 440 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa...
Source: 824
Target: AR protein [Homo sapiens]
External Id: MDAN535
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
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|
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
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Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) sign...
Source: 824
Target: N/A
External Id: MDAV150
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Name: Vibrio cholerae assay for pro-quorum sensing small molecules
Source: Southern Research Specialized Biocontainment Screening Center
Target: cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961]
External Id: Vcholera_QS_Pilot
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Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr
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Name: qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cel...
Source: 824
Target: RecName: Full=ATPase family AAA domain-containing protein 5; AltName: Full=Chromosome fragility-associated gene 1 protein
External Id: ELG271
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Name: Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-SARS-CoV-2-PP
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Name: qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal...
Source: 824
Target: thyroid hormone receptor beta isoform 2 [Rattus norvegicus]
External Id: TRN186
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Name: qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal...
Source: 824
Target: N/A
External Id: TRV455
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 3-ethyl-3-methylglutarimide |
| EINECS 200-588-0 |
| 4-Ethyl-4-methyl-2,6-piperidinedione |
| Bemegrid |
| Ahypnon |
| 4-ethyl-4-methylglutarimide |
| 4-Ethyl-4-methylpiperidine-2,6-dione |
| Antibarbi |
| 3-ethyl-3-methylgluarimide |
| Methetharimide |
| bemegride |
| 4-ethyl-4-methyl-piperidine-2,6-dione |
| MFCD00006673 |
| Zentraleptin |
| Agipnon |
| b,b-Methylethylglutarimide |
| Megimide |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the physical appearance of 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: 4-ethyl-4-methylpiperidine-2,6-dione appears as powder | white. |
| Q: What is the LogP of 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: LogP of 4-ethyl-4-methylpiperidine-2,6-dione is 1.52. |
| Q: What is the melting point of 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: Melting point of 4-ethyl-4-methylpiperidine-2,6-dione is 126-127 °C(lit.). |
| Q: What are the storage conditions for 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: Storage conditions for 4-ethyl-4-methylpiperidine-2,6-dione: −20°C. |
| Q: What is the molecular formula of 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: Molecular formula of 4-ethyl-4-methylpiperidine-2,6-dione is C8H13NO2. |
| Q: What is the safety information for 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: Safety information for 4-ethyl-4-methylpiperidine-2,6-dione: S22-S36/37/39-S45. |
| Q: What is the English name of 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: The English name of 4-ethyl-4-methylpiperidine-2,6-dione is 4-ethyl-4-methylpiperidine-2,6-dione. |
| Q: What is the polar surface area (PSA) of 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: Polar surface area (PSA) of 4-ethyl-4-methylpiperidine-2,6-dione is 46.17000. |
| Q: What English synonyms does 4-ethyl-4-methylpiperidine-2,6-dione have? |
| A: English synonyms of 4-ethyl-4-methylpiperidine-2,6-dione: 3-ethyl-3-methylglutarimide, EINECS 200-588-0, 4-Ethyl-4-methyl-2,6-piperidinedione, Bemegrid, Ahypnon, 4-ethyl-4-methylglutarimide, 4-Ethyl-4-methylpiperidine-2,6-dione, Antibarbi, 3-ethyl-3-methylgluarimide, Methetharimide, bemegride, 4-ethyl-4-methyl-piperidine-2,6-dione, MFCD00006673, Zentraleptin, Agipnon, b,b-Methylethylglutarimide, Megimide. |
| Q: What is the CAS number of 4-ethyl-4-methylpiperidine-2,6-dione? |
| A: CAS number of 4-ethyl-4-methylpiperidine-2,6-dione is 64-65-3. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |