3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride

Modify Date: 2024-09-29 02:18:44

3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride structure	Common Name	3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
	CAS Number	64000-73-3	Molecular Weight	197.23800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈H₁₅N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride

Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].

Name	1-[(6-Hydrazino-3-pyridazinyl)(methyl)amino]-2-propanol
Synonym	More Synonyms

Description	Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vivo	Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay[1]. Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats[2]. Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model[3]. Animal Model: Male and female B6C3F1 and to female BALB/c mice (8 weeks old)[1] Dosage: 100, 200, and 400 ppm dose: 8, 20, and 40 mg/kg/day in B6C3F1 males, 8, 22, and 43 mg/kg/day in B6C3F1 females, and 6, 15, and 34 mg/kg/day in BALB/c females, respectively Administration: Oral gavage; added in the drinking water; provided for 80 weeks, and observed for 130-133 weeks age Result: Resulted over 80% of mice alive beyond 78 weeks of age.

Molecular Formula	C₈H₁₅N₅O
Molecular Weight	197.23800
Exact Mass	197.12800
PSA	90.53000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR6550000

CHEMICAL NAME :: 3(2H)-Pyridazinone, 6-((2-hydroxypropyl)methylamino)-, hydrazone

CAS REGISTRY NUMBER :: 64000-73-3

BEILSTEIN REFERENCE NO. :: 0649354

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H15-N5-O

MOLECULAR WEIGHT :: 197.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 1 mg/plate

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 5,339,1985

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

DESME

propildazine

Propyldazine

TRUST

radar

FORDO

orbit

Dadar

TILT

JUNO

desmel

3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride

Use of 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride

Names

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Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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