3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
Modify Date: 2024-09-29 02:18:44
3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride structure
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Common Name | 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride | ||
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| CAS Number | 64000-73-3 | Molecular Weight | 197.23800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H15N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloridePildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2]. |
| Name | 1-[(6-Hydrazino-3-pyridazinyl)(methyl)amino]-2-propanol |
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| Synonym | More Synonyms |
| Description | Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2]. |
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| Related Catalog | |
| In Vivo | Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay[1]. Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats[2]. Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model[3]. Animal Model: Male and female B6C3F1 and to female BALB/c mice (8 weeks old)[1] Dosage: 100, 200, and 400 ppm dose: 8, 20, and 40 mg/kg/day in B6C3F1 males, 8, 22, and 43 mg/kg/day in B6C3F1 females, and 6, 15, and 34 mg/kg/day in BALB/c females, respectively Administration: Oral gavage; added in the drinking water; provided for 80 weeks, and observed for 130-133 weeks age Result: Resulted over 80% of mice alive beyond 78 weeks of age. |
| Molecular Formula | C8H15N5O |
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| Molecular Weight | 197.23800 |
| Exact Mass | 197.12800 |
| PSA | 90.53000 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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| HS Code | 2933990090 |
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| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| DESME |
| propildazine |
| Propyldazine |
| TRUST |
| radar |
| FORDO |
| orbit |
| Dadar |
| TILT |
| JUNO |
| desmel |