Alternariol

Modify Date: 2024-01-03 15:52:55

Alternariol structure	Common Name	Alternariol
	CAS Number	641-38-3	Molecular Weight	258.226
	Density	1.6±0.1 g/cm3	Boiling Point	586.9±39.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₀O₅	Melting Point	350°C (rough estimate)
	MSDS	Chinese USA	Flash Point	232.3±20.6 °C
	Symbol	GHS06	Signal Word	Danger

Use of Alternariol

Alternariol is a mycotoxin produced by Alternaria species. AOH inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes[1]. Alternariol exhibits a variety of therapeutic and biological properties such as phytotoxicity, cytotoxicity, anti-HIV, anti-cancer, and anti-microbial properties[2].

Name	alternariol
Synonym	More Synonyms

Description	Alternariol is a mycotoxin produced by Alternaria species. AOH inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes[1]. Alternariol exhibits a variety of therapeutic and biological properties such as phytotoxicity, cytotoxicity, anti-HIV, anti-cancer, and anti-microbial properties[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection
References	[1]. Fliszár-Nyúl E, et al. Interaction of Mycotoxin Alternariol with Serum Albumin. Int J Mol Sci. 2019 May 12;20(9). pii: E2352. [2]. Grover S, et al. The Alternaria alternate Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation. Int J Mol Sci. 2017 Jul 20;18(7). pii: E1577.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

Research Areas >> Infection

References

[1]. Fliszár-Nyúl E, et al. Interaction of Mycotoxin Alternariol with Serum Albumin. Int J Mol Sci. 2019 May 12;20(9). pii: E2352.

[2]. Grover S, et al. The Alternaria alternate Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation. Int J Mol Sci. 2017 Jul 20;18(7). pii: E1577.

Density	1.6±0.1 g/cm3
Boiling Point	586.9±39.0 °C at 760 mmHg
Melting Point	350°C (rough estimate)
Molecular Formula	C₁₄H₁₀O₅
Molecular Weight	258.226
Flash Point	232.3±20.6 °C
Exact Mass	258.052826
PSA	90.90000
LogP	2.93
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.731

Alternariol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP8757000

CHEMICAL NAME :: 6H-Dibenzo(b,d)pyran-6-one, 1-methyl-3,7,9-trihydroxy-

CAS REGISTRY NUMBER :: 641-38-3

BEILSTEIN REFERENCE NO. :: 0244839

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H10-O5

MOLECULAR WEIGHT :: 258.24

WISWESSER LINE NOTATION :: T B666 HOVJ C1 EQ KQ MQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 9-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 13-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H310-H330
Precautionary Statements	P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+
Risk Phrases	26/27/28
Safety Phrases	28-36/37/39-45
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	HP8757000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2914400090

Precursor 6
CAS#:7149-90-8 2,4-dimethoxy-6... CAS#:131035-44-4 2,4-dimethoxy-6... CAS#:131035-47-7 3-(2,4-dimethox... CAS#:131035-45-5 ethyl 2,4-dimet...
CAS#:131035-48-8 methyl 3-(2,4-d... CAS#:23452-05-3 alternariol mon...
DownStream 2
CAS#:23452-05-3 alternariol mon... CAS#:979-92-0 SAH

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.

Toxicology 326 , 119-29, (2014)

The mycotoxin alternariol (AOH), a frequent contaminant in fruit and grain, is known to induce cellular stress responses such as reactive oxygen production, DNA damage and cell cycle arrest. Cellular ...

AFLP variability, toxin production, and pathogenicity of Alternaria species from Argentinean tomato fruits and puree.

Int. J. Food Microbiol. 145(2-3) , 414-9, (2011)

Large amounts of tomato fruits and derived products are produced in Argentina and may be contaminated by Alternaria toxins. Limited information is available on the genetic variability, toxigenicity, a...

Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice.

Toxicol. Lett. 214(1) , 46-52, (2012)

Alternaria spp. are known to form a spectrum of secondary metabolites with alternariol (AOH), alternariol monomethyl ether (AME), altenuene (ALT) and tenuazonic acid (TA) as the major mycotoxins with ...

Alternariol

Alternariol from Alternaria sp.

3,7,9-Trihydroxy-1-methyl-6H-benzo[c]chromen-6-one

6H-Dibenzo[b,d]pyran-6-one, 3,7,9-trihydroxy-1-methyl-

AOH

3,7,9-trihydroxy-1-methylbenzo[c]chromen-6-one

BioBioPha
China
Product Name: Alternariol
Price: ￥3400.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Alternariol
Price: ￥4000.0/5mg ￥3278.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Alternariol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Alternariol

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