Necrostatin-1

Modify Date: 2025-08-25 12:02:54

Necrostatin-1 Structure
Necrostatin-1 structure
 Common Name Necrostatin-1
CAS Number 64419-92-7 Molecular Weight 245.30000
Density N/A Boiling Point N/A
Molecular Formula C12H11N3OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Necrostatin-1


Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor[1].

 Names

Name 5-(1H-indol-3-ylmethyl)-2-sulfanylideneimidazolidin-4-one
Synonym More Synonyms

 Necrostatin-1 Biological Activity

Description Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor[1].
Related Catalog
References

[1]. Degterev A, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May;4(5):313-21.  

 Chemical & Physical Properties

Molecular Formula C12H11N3OS
Molecular Weight 245.30000
Exact Mass 245.06200
PSA 99.54000
LogP 1.20610

 Synthetic Route

DL-Tryptophan structure

DL-Tryptophan

CAS#:54-12-6

~%

Necrostatin-1 Structure

Necrostatin-1

CAS#:64419-92-7

Literature: Swan Australian Journal of Scientific Research, Series A: Physical Sciences, 1952 , vol. 5, p. 728,732

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

5-Indol-3-ylmethyl-2-thioxo-imidazolidin-4-on
IN1206
Necrostatin-1,Inactive Control
5-indol-3-ylmethyl-2-thioxo-imidazolidin-4-one
Thiohydantoin-Try
Tryptophanthiohydantoin
Nec-1i
tryptophan 2-thiohydantoin
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