Necrostatin-1

• 常用名: Necrostatin-1
• 英文名: Necrostatin-1
• CAS号: 64419-92-7
• 分子量: 245.30000
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₁N₃OS
• 熔点: N/A
• 闪点: N/A

Necrostatin-1用途

Necrostatin-1 (Nec-1) (inactive control) 是 Necrostatin-1 (HY-15760) 的非活性类似物。Necrostatin-1 是一种有效的坏死性凋亡抑制剂。

Necrostatin-1名称

• 英文名: 5-(1H-indol-3-ylmethyl)-2-sulfanylideneimidazolidin-4-one

Necrostatin-1生物活性

• 描述: Necrostatin-1 (Nec-1) (inactive control) 是 Necrostatin-1 (HY-15760) 的非活性类似物。Necrostatin-1 是一种有效的坏死性凋亡抑制剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Degterev A, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May;4(5):313-21.

Necrostatin-1物理化学性质

• 分子式: C₁₂H₁₁N₃OS
• 分子量: 245.30000
• 精确质量: 245.06200
• PSA: 99.54000
• LogP: 1.20610
• InChIKey: MPLRRPKKFHUEEL-UHFFFAOYSA-N
• SMILES: O=C1NC(=S)NC1Cc1c[nH]c2ccccc12

Necrostatin-1靶点实验

查看更多实验

实验名称：Effective concentration required for inhibition of necroptosis in FADD deficient Jurk... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL885191

实验名称：Inhibition of human RIP1 K45M mutant autophosphorylation expressed in Sf9 cells 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 1 External Id：CHEMBL1221004

实验名称：Inhibition of necroptosis in icv dosed mouse middle cerebral artery occlusion induced... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1266003

实验名称：Inhibition of cellular necroptosis in TNFalpha treated FADD deficient human Jurkat ce... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL1221003

实验名称：Inhibition of human RIP1 K45M mutant autophosphorylation expressed in HEK293T cells 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 1 External Id：CHEMBL1221001

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Necrostatin-1英文别名

• 5-Indol-3-ylmethyl-2-thioxo-imidazolidin-4-on
• IN1206
• Necrostatin-1,Inactive Control
• 5-indol-3-ylmethyl-2-thioxo-imidazolidin-4-one
• Thiohydantoin-Try
• Tryptophanthiohydantoin
• Nec-1i
• tryptophan 2-thiohydantoin