3-aminopropanenitrile,hydrochloride
3-aminopropanenitrile,hydrochloride structure
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Common Name | 3-aminopropanenitrile,hydrochloride | ||
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| CAS Number | 646-03-7 | Molecular Weight | 106.55400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C3H7ClN2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 3-aminopropanenitrile,hydrochlorideβ-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes[1][2]. |
Summary: 3-Aminopropanenitrile hydrochloride, CAS 646-03-7, molecular formula C3H7ClN2, molecular weight 106.55400, for research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 3-aminopropanenitrile,hydrochloride |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes[1][2]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite Lysyl Oxidase |
| In Vitro | β-Aminopropionitrile (BAPN) normalizes the expression of GLUT4 and adiponectin, and improves glucose uptake in an in vitro model of insulin resistance[1]. β-Aminopropionitrile (500 μM, 72 h) blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibits invasion and migration capacities of cervical carcinoma cells in vitro[2]. Western Blot Analysis[1] Cell Line: 3T3-L1 adipocytes Concentration: 200 μM with 1.15 nM and 2.87 nM TNFα Incubation Time: 72 h Result: TNFα reduced expression of GLUT4 and adiponectin, and increased SOCS3 protein levels in these cells. And these effects were prevented. Cell Invasion Assay[2] Cell Line: HeLa and SiHa cells Concentration: 500 μM Incubation Time: 72 h Result: Significantly reduced hypoxia-elicited cell invasion in both cell models. Cell Migration Assay [2] Cell Line: HeLa and SiHa cells Concentration: 500 μM Incubation Time: 72 h Result: Decreased hypoxia-induced migration from 180 and 240% to 60 and 70% in HeLa and SiHa cells, respectively. Western Blot Analysis[2] Cell Line: HeLa and SiHa cells Concentration: 500 μM Incubation Time: 72 h Result: Effectively prevented hypoxia-induced downregulation of E-cadherin and strongly inhibited hypoxia-induced upregulation of α-SMA and vimentin. |
| In Vivo | β-Aminopropionitrile (BAPN) (100 mg/kg/day; p.o.; 6 weeks) reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats[1]. β-Aminopropionitrile monofumarate (1 g/kg/day; p.o.; 4 weeks) induces thoracic aortic dissection in C57BL/6 mice[3]. Animal Model: Male Wistar rats of 150 g, high-fat diet (HFD) model[1] Dosage: 100 mg/kg/day Administration: In the drinking water, 6 weeks Result: Significantly prevented the rise in body weight in HFD rats, but not in animals that were fed a standard diet. Reduced the increase in the weight of white adipose tissue (both epididymal and lumbar) in obese animals and attenuated their enhanced adiposity. Improved fasted glucose and insulin levels and consequently reduced HOMA index in the HFD group. Improved insulin signalling in adipose tissue from obese animals. Animal Model: C57BL/6 mice[3] Dosage: 1 g/kg/day Administration: In the drinking water, 4 weeks Result: Induce thoracic aortic dissection (TAD) in all mice with 24 h of Ang II infusion. Caused 87% of C57BL/6 mice to develop TAD without Ang II. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C3H7ClN2 |
|---|---|
| Molecular Weight | 106.55400 |
| Exact Mass | 106.03000 |
| PSA | 49.81000 |
| LogP | 1.36108 |
| InChIKey | SOWHACJNMKTTRC-UHFFFAOYSA-N |
| SMILES | Cl.N#CCCN |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
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| DownStream 1 | |
CAS#:6640-70-6This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 3-aminopropanenitrile hydrochloride |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of 3-aminopropanenitrile,hydrochloride? |
| A: LogP of 3-aminopropanenitrile,hydrochloride is 1.36108. |
| Q: What is the SMILES notation of 3-aminopropanenitrile,hydrochloride? |
| A: SMILES notation of 3-aminopropanenitrile,hydrochloride is Cl.N#CCCN. |
| Q: What is the English name of 3-aminopropanenitrile,hydrochloride? |
| A: The English name of 3-aminopropanenitrile,hydrochloride is 3-aminopropanenitrile,hydrochloride. |
| Q: What is the molecular weight of 3-aminopropanenitrile,hydrochloride? |
| A: Molecular weight of 3-aminopropanenitrile,hydrochloride is 106.55400. |
| Q: What are the uses of 3-aminopropanenitrile,hydrochloride? |
| A: Main uses of 3-aminopropanenitrile,hydrochloride: β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes[1][2]. |
| Q: What is the molecular formula of 3-aminopropanenitrile,hydrochloride? |
| A: Molecular formula of 3-aminopropanenitrile,hydrochloride is C3H7ClN2. |
| Q: What are the downstream products of 3-aminopropanenitrile,hydrochloride? |
| A: Related downstream products(CAS) of 3-aminopropanenitrile,hydrochloride: 6640-70-6. |
| Q: What is the Chinese name of 646-03-7? |
| A: Chinese name of 646-03-7 is 646-03-7. |
| Q: What is the CAS number of 3-aminopropanenitrile,hydrochloride? |
| A: CAS number of 3-aminopropanenitrile,hydrochloride is 646-03-7. |
| Q: What is the InChIKey of 3-aminopropanenitrile,hydrochloride? |
| A: InChIKey of 3-aminopropanenitrile,hydrochloride is SOWHACJNMKTTRC-UHFFFAOYSA-N. |