gaboxadol

Modify Date: 2025-08-21 12:05:59

gaboxadol structure	Common Name	gaboxadol
	CAS Number	64603-91-4	Molecular Weight	140.140
	Density	1.3±0.1 g/cm3	Boiling Point	340.5±42.0 °C at 760 mmHg
	Molecular Formula	C₆H₉ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	159.7±27.9 °C

Use of gaboxadol

THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1].

Name	THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride
Synonym	More Synonyms

Description	THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	α4β3δ GABAAR:13 μM (EC50)
References	[1]. Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34(49):16256-72.

Density	1.3±0.1 g/cm3
Boiling Point	340.5±42.0 °C at 760 mmHg
Molecular Formula	C₆H₉ClN₂O₂
Molecular Weight	140.140
Flash Point	159.7±27.9 °C
Exact Mass	140.058578
PSA	58.29000
LogP	-0.61
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.551

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY3396800

CHEMICAL NAME :: Isoxazolo(5,4-c)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrate

CAS REGISTRY NUMBER :: 64603-91-4

LAST UPDATED :: 199103

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H8-N2-O2.H2-O

MOLECULAR WEIGHT :: 158.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 98 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982

4,5,6,7-tetrahy...

CAS#:815574-58-4

gaboxadol

CAS#:64603-91-4

Literature: US2005/171142 A1, ; Page/Page column 5 ;

methyl 3,4,5,7-...

CAS#:65202-62-2

gaboxadol

CAS#:64603-91-4

Literature: US4278676 A1, ;

Precursor 2
CAS#:815574-58-4 4,5,6,7-tetrahy... CAS#:65202-62-2 methyl 3,4,5,7-...
DownStream 0

Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one

4,5,6,7-tetrahydroisoxazolo<5,4-c>pyridine-3-ol

3-methoxy-4,5,6,7-tetrahydroisoxazole<5,4-c>pyridinium

Isoxazolo(4,5-d)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-

4,5,6,7-Tetrahydroisoxazolo<5,4-c>-pyridin-3-ol

THIP HYDROCHLORIDE

4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol

4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-3(2H)-one

Gaboxadolum

THPO

4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate

Einecs 264-963-0

Lu 02-030

THIP

gaboxadol

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: THIP
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: gaboxadol
Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg
Purity: 98.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: THIP hydrochloride;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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gaboxadol Biological Activity

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.