64603-91-4

64603-91-4 structure

Name: gaboxadol
Chemical Name: THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride
CAS Number: 64603-91-4
Molecular Formula: C₆H₉ClN₂O₂
Molecular Weight: 140.140
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-03-31 08:00:00
Modify Date: 2024-01-06 09:47:22
THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1].

Name	THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride
Synonyms	Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro- 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one 4,5,6,7-tetrahydroisoxazolo<5,4-c>pyridine-3-ol 3-methoxy-4,5,6,7-tetrahydroisoxazole<5,4-c>pyridinium Isoxazolo(4,5-d)pyridin-3(2H)-one, 4,5,6,7-tetrahydro- 4,5,6,7-Tetrahydroisoxazolo<5,4-c>-pyridin-3-ol THIP HYDROCHLORIDE 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol 4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-3(2H)-one Gaboxadolum THPO 4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate Einecs 264-963-0 Lu 02-030 THIP gaboxadol

Description	THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	α4β3δ GABAAR:13 μM (EC50)
References	[1]. Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34(49):16256-72.

CHEMICAL NAME :: Isoxazolo(5,4-c)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrate

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982

815574-58-4

64603-91-4

Literature: US2005/171142 A1, ; Page/Page column 5 ;

65202-62-2

64603-91-4

Literature: US4278676 A1, ;

Precursor 2
815574-58-4 65202-62-2
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