Azumolene
Modify Date: 2024-01-02 18:17:32
Azumolene structure
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Common Name | Azumolene | ||
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| CAS Number | 64748-79-4 | Molecular Weight | 349.14000 | |
| Density | 1.79g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C13H9BrN4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AzumoleneAzumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research[1][2]. |
| Name | 1-[[5-(4-bromophenyl)-1,3-oxazol-2-yl]methylideneamino]imidazolidine-2,4-dione |
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| Synonym | More Synonyms |
| Description | Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research[1][2]. |
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| Related Catalog | |
| In Vitro | Pretreatment with 20 µM Azumolene for 1-2 min inhibits SOCE activated by subsequent addition of caffeine and ryanodine to promote RyR-dependent sarcoplasmic reticulum Ca2+ store depletion in mouse myotubes and adult muscle fibers[2]. |
| In Vivo | The effect of Azumolene (EU4093) on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg/kg. This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value. The contraction of intrafusal muscle as measured by the response of spindle afferent discharge is also reduced by Azumolene[1]. |
| References |
| Density | 1.79g/cm3 |
|---|---|
| Molecular Formula | C13H9BrN4O3 |
| Molecular Weight | 349.14000 |
| Exact Mass | 347.98600 |
| PSA | 87.80000 |
| LogP | 2.25650 |
| Index of Refraction | 1.739 |
| HS Code | 2934999090 |
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~68%
Azumolene CAS#:64748-79-4 |
| Literature: White, R.L.; Wessels, F.L.; Schwan, T.J.; Ellis, K.O. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 263 - 266 |
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~%
Azumolene CAS#:64748-79-4 |
| Literature: White, R.L.; Wessels, F.L.; Schwan, T.J.; Ellis, K.O. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 263 - 266 |
|
~%
Azumolene CAS#:64748-79-4 |
| Literature: White, R.L.; Wessels, F.L.; Schwan, T.J.; Ellis, K.O. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 263 - 266 |
![2-[(2,4-Dioxo-1-imidazolidinyl)imino]acetic Acid structure](https://image.chemsrc.com/caspic/250/64748-89-6.png)
![[[(2,4-dioxo-1-imidazolidinyl)imino]methyl]formic acid chloride structure](https://image.chemsrc.com/caspic/395/64748-90-9.png)
| Precursor 3 | |
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| DownStream 0 | |
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Azumolenum |
| Azumolenum [Latin] |
| 1-[5-(4-bromo-phenyl)-oxazol-2-ylmethyleneamino]-imidazolidine-2,4-dione |
| Azumolene |
| Azumoleno |
| Azumolene [INN] |
| 1-(((5-(4-bromophenyl)-2-oxazolyl)methylene)amino)-2,4-imidazolidinedione |
| UNII-5U7IO9CV80 |
| Azumoleno [Spanish] |