Latamoxef
Latamoxef structure
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Common Name | Latamoxef | ||
|---|---|---|---|---|
| CAS Number | 64952-97-2 | Molecular Weight | 520.47300 | |
| Density | 1.77 g/cm3 | Boiling Point | 836ºC | |
| Molecular Formula | C20H20N6O9S | Melting Point | 117 - 122ºC | |
| MSDS | USA | Flash Point | N/A | |
Use of LatamoxefMoxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases[1]. |
| Name | moxalactam |
|---|---|
| Synonym | More Synonyms |
| Description | Moxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases[1]. |
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| Related Catalog | |
| Target |
β-lactamases[1] |
| In Vitro | Moxalactam (Latamoxef) inhibits 90% of strains of Escherichia coli, Klebsiella species, Proteus species, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and Salmonella species, including strains which are resistant to Cephalothin (HY-B1275A) and Gentamicin (HY-A0276A) at concentrations of less than 1 μg/mL[1]. Moxalactam exhibits moderate activity against P. aeruginosa and is usually active against other species of Pseudomonas, Acinetobacter species are usually resistant to Moxalactam[1]. Moxalactam has marked stability in vitro against a variety of β-lactamases, including that produced by B. fragilis, inhibits production of β-lactamases and does not induce class I β-lactamase[1]. |
| In Vivo | Moxalactam (Latamoxef) (0-7.4 mg/mouse; s.c.; once) is effective against bacterial infections in mice[2]. Animal Model: Four-week-old male strain ICR mice, weighing 18-20 g, bacterial infection model[2] Dosage: 0-7.4 mg/mouse Administration: Subcutaneous injection, once Result: Showed protective activity with ED50s less than 7.4 mg/mouse against gram-positive and gram-negative bacterial infected mice. |
| References |
| Density | 1.77 g/cm3 |
|---|---|
| Boiling Point | 836ºC |
| Melting Point | 117 - 122ºC |
| Molecular Formula | C20H20N6O9S |
| Molecular Weight | 520.47300 |
| Exact Mass | 520.10100 |
| PSA | 231.60000 |
| Index of Refraction | 1.768 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | RN6824500 |
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A potential substrate binding conformation of β-lactams and insight into the broad spectrum of NDM-1 activity.
Antimicrob. Agents Chemother. 56(10) , 5157-63, (2012) New Delhi metallo-β-lactamase 1 (NDM-1) is a key enzyme that the pathogen Klebsiella pneumonia uses to hydrolyze almost all β-lactam antibiotics. It is currently unclear why NDM-1 has a broad spectrum... |
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Comparison of cefoxitin and moxalactam 30 microg disc diffusion methods for detection of methicillin resistance in coagulase-negative staphylococci.
J. Antimicrob. Chemother. 59(4) , 763-6, (2007) To compare cefoxitin and/or moxalactam 30 microg disc diffusion (DD) methods to detect methicillin resistance in coagulase-negative staphylococci (CoNS) using both high- and low-density (HD/LD) inocul... |
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Phosphate deprivation is associated with high resistance to latamoxef of gel-entrapped, sessile-like Escherichia coli cells.
J. Antimicrob. Chemother. 49(2) , 315-20, (2002) Viable Escherichia coli cells were entrapped in agar gel layers and incubated in a phosphate-limited glucose medium. Immobilized bacteria displayed enhanced alkaline phosphatase activity and overexpre... |
| 5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid,7-((carboxy(4-hydroxyphenyl)acetyl) amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo |
| 7-((Carboxy(4-hydroxyphenyl)acetyl)amino)-7-methoxy-(3-((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Latamoxef |
| lamoxactam |
| (R)-Moxalactam |
| 5-oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((carboxy(4-hydroxyphen |
| Listeria MOX Supplement,Moxalactam |
| Oxa-cephem |
| yl)acetyl)amino)-7-methoxy-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo |
| LMOX |