(D-Ala2)-Leu-Enkephalin

Modify Date: 2024-01-13 17:28:48

(D-Ala2)-Leu-Enkephalin Structure
(D-Ala2)-Leu-Enkephalin structure
Common Name (D-Ala2)-Leu-Enkephalin
CAS Number 64963-01-5 Molecular Weight 569.649
Density 1.3±0.1 g/cm3 Boiling Point 991.9±65.0 °C at 760 mmHg
Molecular Formula C29H39N5O7 Melting Point N/A
MSDS USA Flash Point 553.7±34.3 °C

 Use of (D-Ala2)-Leu-Enkephalin


[D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin. Sequence: Tyr-D-Ala-Gly-Phe-Leu.

 Names

Name 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
Synonym More Synonyms

 (D-Ala2)-Leu-Enkephalin Biological Activity

Description [D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin. Sequence: Tyr-D-Ala-Gly-Phe-Leu.
Related Catalog

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 991.9±65.0 °C at 760 mmHg
Molecular Formula C29H39N5O7
Molecular Weight 569.649
Flash Point 553.7±34.3 °C
Exact Mass 569.284973
PSA 199.95000
LogP 2.42
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.582
Storage condition −20°C

 Safety Information

RIDADR NONH for all modes of transport
WGK Germany 3

 Articles5

More Articles
Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation.

Biochem. J. 320 , 227-235, (1996)

Rat-1 fibroblasts were transfected with a cDNA encoding the mouse delta opioid receptor. Two separate clones, D2 (which expressed some 6 pmol of the receptor/mg of membrane protein) and DOE (which exp...

Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.

Anesthesiology 93 , 1053-1063, (2000)

The mechanism underlying the depressant effect of opioids on neuronal activity within the neocortex is still not clear. Three modes of action have been suggested: (1) inhibition by activation of posts...

Direct excitatory opiate effects mediated by non-synaptic actions on rat medial vestibular neurons.

Eur. J. Pharmacol. 262 , 99-106, (1994)

Opiates increase firing of rat medial vestibular nucleus neurons. We have attempted to determine the mechanism of these excitatory opiate actions by extracellular recording of neuronal activity with i...

 Synonyms

N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-L-leucine
D-Ala(2)-Leu(5)-Enk
TYR-D-ALA-GLY-PHE-LEU
Leucine, tyrosylalanylglycylphenylalanyl-
D-Ala2,D-Leu5-enkephalin
Tyrosylalanylglycylphenylalanylleucine
D-ALA2-LEU5-ENKEPHALIN
D-(Ala)2-leucine enkephalin
[D-Ala2]-Leucine enkephalin
Tyr-D-Ala-Gly-Phe-Leu
H-TYR-D-ALA-GLY-PHE-LEU-OH
L-Tyr-D-Ala-Gly-L-Phe-L-Leu-OH
(D-ALA2)-LEU-ENKEPHALIN
Tyr-D-Ala-Gly-Phe-Leu-OH
(D-alanine2)leucine enkephalin
Pentapeptide-18
Leuphasyl
[D-Ala2]leucine-enkephalin
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