Boc-Leu-Gly-Arg-AMC acetate salt

Modify Date: 2024-01-02 18:18:33

Boc-Leu-Gly-Arg-AMC acetate salt Structure
Boc-Leu-Gly-Arg-AMC acetate salt structure
Common Name Boc-Leu-Gly-Arg-AMC acetate salt
CAS Number 65147-09-3 Molecular Weight 601.69400
Density N/A Boiling Point N/A
Molecular Formula C29H43N7O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Boc-Leu-Gly-Arg-AMC acetate salt


Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays[1][2].

 Names

Name Boc-Leu-Gly-Arg-AMC
Synonym More Synonyms

 Boc-Leu-Gly-Arg-AMC acetate salt Biological Activity

Description Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays[1][2].
Related Catalog
In Vitro To demonstrate the presence in the abdominal gland of proteolytic enzymes capable of generating Sodefrin, an enzymatic assay was developed using Boc-Leu-Gly-Arg-AMC as synthetic substrate. A crude extract of the abdominal gland hydrolyzed Boc-Leu-Gly-Arg-AMC to liberate 7-amino-4- methylcoumarin, suggesting that enzymes that generate sodefrin from its precursor molecule are present in the gland. The activity in the extract for cleaving Boc-Leu-Gly-Arg-AMC is optimal at pH 9.0 and 45 ℃[1].
References

[1]. Nakada T, et al. Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster, that generate sodefrin from its biosynthetic precursor. Zoolog Sci. 2007 May;24(5):521-4.

[2]. Yumiko Obayashi, et al. Proteolytic enzymes in coastal surface seawater: Significant activity of endopeptidases and exopeptidases Limnol. Oceanogr., 50(2), 2005, 722-726.

 Chemical & Physical Properties

Molecular Formula C29H43N7O7
Molecular Weight 601.69400
Exact Mass 601.32200
PSA 217.74000
LogP 4.28020
Storage condition -20°C

 Synonyms

tert-butyl N-[1-[[2-[[5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
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