12,14-Dichlorodehydroabietic acid

Modify Date: 2026-08-07 01:38:35

12,14-Dichlorodehydroabietic acid structure	Common Name	12,14-Dichlorodehydroabietic acid
	CAS Number	65281-77-8	Molecular Weight	369.32500
	Density	1.2g/cm3	Boiling Point	469.6ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₆Cl₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	237.8ºC

Use of 12,14-Dichlorodehydroabietic acid

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].

Name	(1R,4aS,10aR)-6,8-dichloro-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid
Synonym	More Synonyms

Description	12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	Ca2+-activated K+ (BK) channel[2] GABAA[1]
References	[1]. R A Nicholson, et al. Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain. Br J Pharmacol. 1999 Mar;126(5):1123-32. [2]. Kazuho Sakamoto, et al. Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. J Pharmacol Exp Ther. 2006 Jan;316(1):144-53.

Density	1.2g/cm3
Boiling Point	469.6ºC at 760 mmHg
Molecular Formula	C₂₀H₂₆Cl₂O₂
Molecular Weight	369.32500
Flash Point	237.8ºC
Exact Mass	368.13100
PSA	37.30000
LogP	6.21170
Index of Refraction	1.555
InChIKey	RKQWIQSTFSBVMQ-CDHQVMDDSA-N
SMILES	CC(C)c1c(Cl)cc2c(c1Cl)CCC1C(C)(C(=O)O)CCCC21C

dehydroabietic acid

CAS#:1740-19-8

~39%

12,14-Dichlorod...

CAS#:65281-77-8

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Literature: Cui, Yong-Mei; Yasutomi, Eriko; Otani, Yuko; Ido, Katsutoshi; Yoshinaga, Takashi; Sawada, Kohei; Ohwada, Tomohiko Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 24 p. 8642 - 8659

Name: Channel opening activity at human BKalpha channel expressed in CHOK1 cells assessed a...
Source: ChEMBL
Target: Calcium-activated potassium channel subunit alpha-1
External Id: CHEMBL998585

Name: Activation of human BKalpha channel expressed in CHOK1 cells assessed as increase in ...
Source: ChEMBL
Target: Calcium-activated potassium channel subunit alpha-1
External Id: CHEMBL989771

Name: Activation of human BKalpha channel expressed in CHOK1 cells assessed as increase in ...
Source: ChEMBL
Target: Calcium-activated potassium channel subunit alpha-1
External Id: CHEMBL943670

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12,14-DICHLORODEHYDROABIETIC ACID

1-Phenanthrenecarboxylic acid,6,8-dichloro-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-,(1R,4aS,10aR)