1-Oleoyl lysophosphatidic acid

Modify Date: 2024-01-21 09:07:00

1-Oleoyl lysophosphatidic acid Structure
1-Oleoyl lysophosphatidic acid structure
Common Name 1-Oleoyl lysophosphatidic acid
CAS Number 65528-98-5 Molecular Weight 436.520
Density 1.1±0.1 g/cm3 Boiling Point 581.5±60.0 °C at 760 mmHg
Molecular Formula C21H41O7P Melting Point N/A
MSDS N/A Flash Point 305.5±32.9 °C

 Use of 1-Oleoyl lysophosphatidic acid


1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation[1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity[2].

 Names

Name [(2R)-2-hydroxy-3-phosphonooxypropyl] octadec-9-enoate
Synonym More Synonyms

 1-Oleoyl lysophosphatidic acid Biological Activity

Description 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation[1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity[2].
Related Catalog
In Vivo 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) (0.4-2 μg; i.c.v.; 9-week-old male Wistar rats) induces anxiety-like responses in the elevated plus maze (EPM) under novelty conditions[1]. Animal Model: 9-week-old male Wistar rats[1] Dosage: 0.4-2 μg Administration: I.c.v. Result: Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM.
References

[1]. Castilla-Ortega E, et al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014;9(1):e85348. Published 2014 Jan 7.

[2]. Perkins LM, et al. Activation of serum response element-regulated genes by lysophosphatidic acid. Nucleic Acids Res. 1994;22(3):450-452.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 581.5±60.0 °C at 760 mmHg
Molecular Formula C21H41O7P
Molecular Weight 436.520
Flash Point 305.5±32.9 °C
Exact Mass 436.259003
PSA 123.10000
LogP 6.18
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.490
Storage condition -20°C

 Synonyms

9-Octadecenoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester, (9Z)-
(2R)-2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate
(2R)-2-Hydroxy-3-(phosphonooxy)propyl (9Z)-9-octadecenoate