1-Oleoyl lysophosphatidic acid

• 常用名: 1-Oleoyl lysophosphatidic acid
• 英文名: 1-Oleoyl lysophosphatidic acid
• CAS号: 65528-98-5
• 分子量: 436.520
• 密度: 1.1±0.1 g/cm3
• 沸点: 581.5±60.0 °C at 760 mmHg
• 分子式: C₂₁H₄₁O₇P
• 熔点: N/A
• 闪点: 305.5±32.9 °C

1-Oleoyl lysophosphatidic acid用途

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) 是一种丰富的溶血磷脂酸种类,由于其对 LPA 受体 (LPA receptors) 的强亲和力,具有很高的生物活性。1-Oleoyl lysophosphatidic acid 在大多数实验室中常用作 LPA 受体激活的试剂。1-Oleoyl lysophosphatidic acid 可增加 SRE 驱动的 β-galactosidase 的活性。

1-Oleoyl lysophosphatidic acid名称

• 中文名: 1-油酰基溶血磷脂酸
• 英文名: [(2R)-2-hydroxy-3-phosphonooxypropyl] octadec-9-enoate

1-Oleoyl lysophosphatidic acid生物活性

• 描述: 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) 是一种丰富的溶血磷脂酸种类,由于其对 LPA 受体 (LPA receptors) 的强亲和力,具有很高的生物活性。1-Oleoyl lysophosphatidic acid 在大多数实验室中常用作 LPA 受体激活的试剂。1-Oleoyl lysophosphatidic acid 可增加 SRE 驱动的 β-galactosidase 的活性。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
  研究领域 >> 神经疾病
• 体内研究: 1-油酰溶血磷脂酸(1-油酰-sn-甘油-3-磷酸)(0.4-2μ克；i、 c.v。；9周龄雄性Wistar大鼠在新奇条件下在高架正迷宫(EPM)中诱导焦虑样反应[1]。动物模型：9周龄雄性Wistar大鼠[1]剂量：0.4-2μg给药：I.c.v.结果：在EPM中,在新奇条件下减少开放臂探索,在习惯性条件下没有效果。
• 参考文献:

  [1]. Castilla-Ortega E, et al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014;9(1):e85348. Published 2014 Jan 7.

  [2]. Perkins LM, et al. Activation of serum response element-regulated genes by lysophosphatidic acid. Nucleic Acids Res. 1994;22(3):450-452.

1-Oleoyl lysophosphatidic acid物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 581.5±60.0 °C at 760 mmHg
• 分子式: C₂₁H₄₁O₇P
• 分子量: 436.520
• 闪点: 305.5±32.9 °C
• 精确质量: 436.259003
• PSA: 123.10000
• LogP: 6.18
• InChIKey: WRGQSWVCFNIUNZ-GDCKJWNLSA-N
• SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCC(O)COP(=O)(O)O
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.490
• 储存条件: -20°C

1-Oleoyl lysophosphatidic acid靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 3 External Id：CHEMBL3363673

实验名称：Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cel... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 1 External Id：CHEMBL4610704

实验名称：Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 1 External Id：CHEMBL3363671

实验名称：Agonist activity at FLAG-tagged human LPA5 expressed in rat B103 cells by Fura-2AM dy... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 5 External Id：CHEMBL3363677

实验名称：Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobi... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 4 External Id：CHEMBL3363675

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：Effect on Ca2+ mobilization in empty vector transfected LPA1xLPA2 double knockout mou... 来源：ChEMBL 靶标：MEF External Id：CHEMBL3363957

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Effect on Ca2+ mobilization in empty vector transfected rat B103 cells by Fura-2AM dy... 来源：ChEMBL 靶标：B103 cell line External Id：CHEMBL3363961

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1-Oleoyl lysophosphatidic acid英文别名

• (2R)-2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate
• (2R)-2-Hydroxy-3-(phosphonooxy)propyl (9Z)-9-octadecenoate