Romifidine

Modify Date: 2026-08-06 15:28:29

Romifidine Structure
Romifidine structure
Common Name Romifidine
CAS Number 65896-16-4 Molecular Weight 258.090
Density 1.7±0.1 g/cm3 Boiling Point 303.2±52.0 °C at 760 mmHg
Molecular Formula C9H9BrFN3 Melting Point 110 °C
MSDS N/A Flash Point 137.2±30.7 °C

 Use of Romifidine


Romifidine is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo[1][2].

 Names

Name N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Synonym More Synonyms

 Romifidine Biological Activity

Description Romifidine is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo[1][2].
Related Catalog
In Vivo Romifidine (80 μg/kg; i.v. once) produces sedative effects with significantly greater drooping during the 45-90 min time period in welsh mountain ponies[1]. Romifidine (40, 80 and 120 mg/kg; i.v. at seven-day intervals) shows a shallower and shorter-lived sedation than with detomidine in horses[2].
References

[1]. England GC, et al. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. J Vet Pharmacol Ther. 1992 Jun;15(2):194-201.  

[2]. Hamm D, et al. Sedative and analgesic effects of detomidine and romifidine in horses. Vet Rec. 1995 Apr 1;136(13):324-7.  

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 303.2±52.0 °C at 760 mmHg
Melting Point 110 °C
Molecular Formula C9H9BrFN3
Molecular Weight 258.090
Flash Point 137.2±30.7 °C
Exact Mass 256.996368
PSA 36.42000
LogP 1.02
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.662
InChIKey KDPNLRQZHDJRFU-UHFFFAOYSA-N
SMILES Fc1cccc(Br)c1NC1=NCCN1

 Safety Information

HS Code 2933290090

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 RomifidineBioassay

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Name: AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: ULK1_INH_LUMI_1536_1X%INH PRUN
Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p
Name: Primary qHTS for Vero E6 cytotoxicity: counterscreen for inhibitors of SARS-S pseudo-...
Source: NCGC
Target: N/A
External Id: TRND-SARS-cytotox-48hr-p1-npc
Name: Primary qHTS for inhibitors of MERS-S pseudo-typed particle cell entry
Source: NCGC
Target: N/A
External Id: TRND-MERS-PP-p1-npc
Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr
Name: Primary qHTS for Huh7 cytotoxicity: counterscreen for inhibitors of MERS-S pseudotype...
Source: NCGC
Target: N/A
External Id: TRND-MERS-cytotox-48hr-p1-npc
Name: Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-SARS-CoV-2-PP
Name: Primary qHTS for inhibitors of SARS-S pseudo-typed particle cell entry
Source: NCGC
External Id: TRND-SARS-PP-p1-npc
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 Synonyms

Romifidina [Spanish]
2-(6-bromo-2-fluorophenylimino)-imidazolidine
Romifidinum [Latin]
2-bromo-6-fluoro-N-(2-imidazolidinylidene)-benzamine
2-[(2-bromo-6-fluorophenyl)-imino]-imidazolidine
N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
2-[(2-Brom-6-fluorphenyl)imino]imidazolidin
Romifidina
Romifidinum
N-(2-bromo-6-fluoro-phenyl)-4,5-dihydro-1H-imidazol-2-amine
(2-bromo-6-fluoro-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine
Romifidine
Sedivet
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