PHENIPRAZINE HYDROCHLORIDE

Modify Date: 2024-01-14 22:11:21

PHENIPRAZINE HYDROCHLORIDE Structure
PHENIPRAZINE HYDROCHLORIDE structure
Common Name PHENIPRAZINE HYDROCHLORIDE
CAS Number 66-05-7 Molecular Weight 186.68200
Density N/A Boiling Point N/A
Molecular Formula C9H15ClN2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PHENIPRAZINE HYDROCHLORIDE


Pheniprazine hydrochloride is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression[1].

 Names

Name 1-phenylpropan-2-ylhydrazine,hydrochloride

 PHENIPRAZINE HYDROCHLORIDE Biological Activity

Description Pheniprazine hydrochloride is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression[1].
Related Catalog
References

[1]. HORITA A. beta-Phenylisopropylhydrazine, a potent and long acting monoamine oxidase inhibitor. J Pharmacol Exp Ther.  

[2]. Stein, Larry, et al. Accelerated recovery from reserpine depression by monoamine oxidase inhibitors.

 Chemical & Physical Properties

Molecular Formula C9H15ClN2
Molecular Weight 186.68200
Exact Mass 186.09200
PSA 38.05000
LogP 2.97410

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MV7400000
CHEMICAL NAME :
Hydrazine, (alpha-methylphenethyl)-, monohydrochloride
CAS REGISTRY NUMBER :
66-05-7
LAST UPDATED :
199206
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C9-H14-N2.Cl-H
MOLECULAR WEIGHT :
186.71
WISWESSER LINE NOTATION :
ZM1Y1&R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 18,617,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
112 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,20,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
87 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
66 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966