STRYCHNINE NITRATE

Modify Date: 2024-01-02 10:54:54

STRYCHNINE NITRATE Structure
STRYCHNINE NITRATE structure
Common Name STRYCHNINE NITRATE
CAS Number 66-32-0 Molecular Weight 397.42400
Density N/A Boiling Point 634.3ºC at 760 mmHg
Molecular Formula C21H23N3O5 Melting Point N/A
MSDS N/A Flash Point 337.4ºC

 Names

Name strychnine nitrate
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 634.3ºC at 760 mmHg
Molecular Formula C21H23N3O5
Molecular Weight 397.42400
Flash Point 337.4ºC
Exact Mass 397.16400
PSA 98.83000
LogP 2.27090

 MSDS


Section I.Chemical Product and Company Identification
Chemical Name Strychnine Nitrate
Portland OR
SynonymStrychnine nitrate salt
Chemical FormulaC21H22N2O2•HNO3
66-32-0
CAS Number

Section II.Composition and Information on Ingredients
Toxicology Data
Chemical NameCAS Number Percent (%)TLV/PEL
Strychnine Nitrate66-32-0Min. 99.0 (T) Not available.Rat LD50 (oral) 16mg/kg
Mouse LD50 (oral) 0.93mg/kg
Rabbit LD50 (intravenous)
0.25mg/kg

Section III. Hazards Identification
Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or
Acute Health Effects
death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
CARCINOGENIC EFFECTS : Not available.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
Toxicity to the reproductive system: Not available. Repeated or prolonged exposure to the substance can produce target
organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an
accumulation in one or many human organs.

Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. DO NOT use an eye ointment. Flush eyes with running water for a minimum of 15
minutes, occasionally lifting the upper and lower eyelids. Seek medical attention.
Skin ContactIf the chemical gets spilled on a clothed portion of the body, remove the contaminated clothes as quickly as possible,
protecting your own hands and body. Place the victim under a deluge shower. If the chemical touches the victim's exposed
skin, such as the hands: Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be
particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. If irritation persists,
seek medical attention. Wash any contaminated clothing before reusing.
InhalationIf the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
IngestionINDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive. SEEK IMMEDIATE MEDICAL ATTENTION in
case of ingestion of a radioactive material.

Section V.Fire and Explosion Data
Not available.
FlammabilityNot available.Auto-Ignition
Not available.
Flash PointsNot available.Flammable Limits
Combustion ProductsThese products include toxic carbon oxides (CO,CO2), nitrogen oxides (NO, NO2).
Fire Hazards
No specific information is available regarding the flammability of this compound in the presence of various materials.
Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
No additional information is available regarding the risks of explosion.
Fire Fighting MediaSMALL FIRE: Use DRY chemicals, CO2, water spray or foam.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
Strychnine Nitrate

Section VI.Accidental Release Measures
Spill CleanupHighly toxic material.
Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
Instructions
assistance on disposal.

Section VII. Handling and Storage
HIGHLY TOXIC COMPOUND. Keep locked up. LIGHT SENSITIVE--store in a darkened cabinet or closet. Keep away from
Handling and Storage
heat and sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all
Information
equipment containing material. DO NOT ingest. DO NOT breathe dust. In case of insufficient ventilation, wear suitable
respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with
skin and eyes.
Always store away from incompatible compounds such as oxidizing agents, alkalis, alkali carbonates and bicarbonates,
benzoates, dichromates, bromides, iodides, tannic and picric acids, salicyclates, borax, gold chlorides, and piperazine.

Section VIII. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator should be used to avoid
Personal Protection
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Not available.
Exposure Limits

Section IX. Physical and Chemical Properties
Physical state @ 20°CSolid. (Powder.)Solubility
Soluble in water, ethanol, chloroform,
glycerol.
Not available.Insoluble in ether.
Specific Gravity
Molecular Weight397.43Partition CoefficientNot available.
Boiling PointNot available.Vapor PressureNot available.
Not available.Not available.
Melting PointVapor Density
Refractive IndexNot available.VolatilityNot available.
Not available.Odorless.
Critical TemperatureOdor
Not available.Not available.
ViscosityTaste

Section X.Stability and Reactivity Data

This material is stable if stored under proper conditions. (See Section VII for instructions)
Stability
Conditions of InstabilityLIGHT SENSITIVE.
Incompatibilities
Highly reactive with oxidizing agents, alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides,
tannic and picric acids, salicyclates, borax, gold chlorides, and piperazine. .

Section XI. Toxicological Information
WL2450000
RTECS Number
Ingestion. Inhalation. Eye contact. Skin contact.
Routes of Exposure
Rat LD50 (oral) 16mg/kg
Toxicity Data
Mouse LD50 (oral) 0.93mg/kg
Rabbit LD50 (intravenous) 0.25mg/kg
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
Toxicity to the reproductive system: Not available. Repeated or prolonged exposure to the substance can produce target
organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an
accumulation in one or many human organs.
Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or
Acute Toxic Effects
death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Continued on Next Page
Strychnine Nitrate

Section XII.Ecological Information
EcotoxicityNot available.
Not available.
Environmental Fate

Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state, and local regulations when disposing of this substance.

Section XIV. Transport Information
DOT ClassificationDOT CLASS 6.1: Poisonous material.
PIN Number
Proper Shipping NameStrychnine salts.
I
Packing Group (PG)
DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationWHMIS CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
(Canada)
EINECS Number (EEC) 200-627-1
EEC Risk StatementsR26/27/28- Very toxic by inhalation, in contact with skin and if swallowed.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WL2450000
CHEMICAL NAME :
Strychnine, mononitrate
CAS REGISTRY NUMBER :
66-32-0
LAST UPDATED :
199709
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C21-H22-N2-O2.H-N-O3
MOLECULAR WEIGHT :
397.47
WISWESSER LINE NOTATION :
T6 G656 B7 C6 E5 D 5ABCEF A& FX MNV QO VN SU AHT&&TTTTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,377,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - tetany
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 187,607,1937
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1778,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
930 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 22,425,1984
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,458,1967
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1778,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 207,688,1949
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
250 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 21,1,1958
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
20 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 131,171,1928
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraarterial
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 131,171,1928

 Safety Information

Hazard Codes T+: Very toxic;
Risk Phrases R26/27/28
Safety Phrases S22-S36/37/39-S45
RIDADR UN 1692 6.1/PG 1
WGK Germany 3
RTECS WL2450000
Packaging Group I
Hazard Class 6.1(a)

 Synonyms

strychnidin-10-one,nitrate
StrychnineHCL,(L-A046)
Strychnin-Nitrat
strychnine,mononitrate
Strychninenitrate,(L-A044)
strychnidin-10-one,mononitrate
(-)-strychnine nitrate
EINECS 200-627-1
(-)-strychninium nitrate
MFCD00078519
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