cimicifugoside

Modify Date: 2024-01-09 20:03:59

cimicifugoside Structure
cimicifugoside structure
 Common Name cimicifugoside
CAS Number 66176-93-0 Molecular Weight 674.81800
Density 1.38 g/cm3 Boiling Point N/A
Molecular Formula C37H54O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of cimicifugoside


Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2].

 Names

Name cimicifugoside
Synonym More Synonyms

 cimicifugoside Biological Activity

Description Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2].
Related Catalog
Target

Nucleoside transport[1]

References

[1]. Yawata A, et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. Eur J Pharm Sci. 2009 Nov 5;38(4):355-61.

[2]. Hemmi H, et al. The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. J Pharmacobiodyn. 1980 Dec;3(12):643-8.

 Chemical & Physical Properties

Density 1.38 g/cm3
Molecular Formula C37H54O11
Molecular Weight 674.81800
Exact Mass 674.36700
PSA 156.67000
LogP 2.94870
Index of Refraction 1.619

 Synonyms

Prim-O-glucosylcimifygin
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