BL-140
Modify Date: 2023-01-18 15:57:08
BL-140 structure
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Common Name | BL-140 | ||
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| CAS Number | 663620-66-4 | Molecular Weight | 371.459 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H21N5O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BL-140A novel specific p110β inhibitor with IC50 of 5.74 nM; dispalys 150-fold and 745-fold selectivity over p110α or p110δ; blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells. |
| Name | BL-140 |
|---|
| Description | A novel specific p110β inhibitor with IC50 of 5.74 nM; dispalys 150-fold and 745-fold selectivity over p110α or p110δ; blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells. |
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| References | References 1. He C, et al. Prostate. 2017 Aug;77(11):1187-1198. View Related Products by Target PI3K |
| Molecular Formula | C18H21N5O2S |
|---|---|
| Molecular Weight | 371.459 |