BL-140

Modify Date: 2025-09-26 17:16:59

BL-140 Structure
BL-140 structure
 Common Name BL-140
CAS Number 663620-66-4 Molecular Weight 371.459
Density N/A Boiling Point N/A
Molecular Formula C18H21N5O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BL-140


A novel specific p110β inhibitor with IC50 of 5.74 nM; dispalys 150-fold and 745-fold selectivity over p110α or p110δ; blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells.

 Names

Name BL-140

 BL-140 Biological Activity

Description A novel specific p110β inhibitor with IC50 of 5.74 nM; dispalys 150-fold and 745-fold selectivity over p110α or p110δ; blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells.
References References 1. He C, et al. Prostate. 2017 Aug;77(11):1187-1198. View Related Products by Target PI3K

 Chemical & Physical Properties

Molecular Formula C18H21N5O2S
Molecular Weight 371.459
InChIKey DKYOLXMEUOJGQB-UHFFFAOYSA-N
SMILES Cc1cc(C(C)Nc2nccs2)c2nc(N3CCOCC3)cc(=O)n2c1
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Chemsrc provides BL-140(CAS#:663620-66-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BL-140 are included as well.>> amp version: BL-140

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