663620-66-4
663620-66-4 structure
- Name: BL-140
- Chemical Name: BL-140
- CAS Number: 663620-66-4
- Molecular Formula: C18H21N5O2S
- Molecular Weight: 371.459
- Create Date: 2020-01-16 17:31:15
- Modify Date: 2023-01-18 15:57:08
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A novel specific p110β inhibitor with IC50 of 5.74 nM; dispalys 150-fold and 745-fold selectivity over p110α or p110δ; blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells.
| Name | BL-140 |
|---|
| Description | A novel specific p110β inhibitor with IC50 of 5.74 nM; dispalys 150-fold and 745-fold selectivity over p110α or p110δ; blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells. |
|---|---|
| References | References 1. He C, et al. Prostate. 2017 Aug;77(11):1187-1198. View Related Products by Target PI3K |
| Molecular Formula | C18H21N5O2S |
|---|---|
| Molecular Weight | 371.459 |