H-Trp-Phe-OH

Modify Date: 2025-08-25 19:40:58

H-Trp-Phe-OH structure	Common Name	H-Trp-Phe-OH
	CAS Number	6686-02-8	Molecular Weight	351.39900
	Density	1.319g/cm3	Boiling Point	688.3ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₁N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	370.1ºC

Use of H-Trp-Phe-OH

H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice[1][2].

Name	Trp-Phe
Synonym	More Synonyms

Description	H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
References	[1]. Zhao YQ, et al. Eight antihypertensive peptides from the protein hydrolysate of Antarctic krill (Euphausia superba): Isolation, identification, and activity evaluation on human umbilical vein endothelial cells (HUVECs). Food Res Int. 2019 Jul;121:197-204. [2]. Pitkow et al. Pharmacological effect of dipeptides on ovarian and uterine weights in immature mice. IRCS Medical Science: Library Compendium (1977), 5(8), 378.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

References

[1]. Zhao YQ, et al. Eight antihypertensive peptides from the protein hydrolysate of Antarctic krill (Euphausia superba): Isolation, identification, and activity evaluation on human umbilical vein endothelial cells (HUVECs). Food Res Int. 2019 Jul;121:197-204.

[2]. Pitkow et al. Pharmacological effect of dipeptides on ovarian and uterine weights in immature mice. IRCS Medical Science: Library Compendium (1977), 5(8), 378.

Density	1.319g/cm3
Boiling Point	688.3ºC at 760 mmHg
Molecular Formula	C₂₀H₂₁N₃O₃
Molecular Weight	351.39900
Flash Point	370.1ºC
Exact Mass	351.15800
PSA	108.21000
LogP	2.94100
Index of Refraction	1.671
InChIKey	IMMPMHKLUUZKAZ-WMZOPIPTSA-N
SMILES	NC(Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccccc1)C(=O)O

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY7582000

CHEMICAL NAME :: Alanine, 3-phenyl-N-tryptophyl-, L-

CAS REGISTRY NUMBER :: 6686-02-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N3-O3

MOLECULAR WEIGHT :: 351.44

WISWESSER LINE NOTATION :: T56 BMJ D1YZVMYVQ1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 150 mg/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4, 1969-71(?). Discontinued. For publisher information, see BIREBV. Volume(issue)/page/year: 20(Suppl 1),133A,1979

HS Code	2933990090

Precursor 0
DownStream 1
CAS#:78440-76-3 3-Methoxymethyl...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-[[2-amino-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoic acid

L-tryptophyl-L-Phenylalanine

tryptophyl-L-phenylalanine

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H-Trp-Phe-OH

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.