Alclometasone
Modify Date: 2024-01-04 12:43:01
Alclometasone structure
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Common Name | Alclometasone | ||
|---|---|---|---|---|
| CAS Number | 67452-97-5 | Molecular Weight | 408.91600 | |
| Density | 1.34g/cm3 | Boiling Point | 607.1ºC at 760mmHg | |
| Molecular Formula | C22H29ClO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 320.9ºC | |
Use of AlclometasoneAlclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1]. |
| Name | alclometasone |
|---|---|
| Synonym | More Synonyms |
| Description | Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1]. |
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| Related Catalog | |
| Target |
IC50: glucocorticoid receptor[1] |
| In Vivo | The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2]. |
| References |
[1]. Alclometasone |
| Density | 1.34g/cm3 |
|---|---|
| Boiling Point | 607.1ºC at 760mmHg |
| Molecular Formula | C22H29ClO5 |
| Molecular Weight | 408.91600 |
| Flash Point | 320.9ºC |
| Exact Mass | 408.17000 |
| PSA | 94.83000 |
| LogP | 2.02090 |
| Index of Refraction | 1.607 |
| HS Code | 2942000000 |
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| Precursor 1 | |
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| DownStream 0 | |
CAS#:66734-13-2| HS Code | 2942000000 |
|---|
| (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| alcometasone |
| 136H45TB7B |
| 7alpha-Chloro-16alpha-methylprednisolone |
| UNII-136H45TB7B |
| Alclomethasone |
| Aclometasone |