Cloricromene

Modify Date: 2024-01-03 01:28:49

Cloricromene Structure
Cloricromene structure
Common Name Cloricromene
CAS Number 68206-94-0 Molecular Weight 395.87700
Density 1.189g/cm3 Boiling Point 514.1ºC at 760mmHg
Molecular Formula C20H26ClNO5 Melting Point 221-222.3ºC
MSDS Chinese Flash Point 264.7ºC

 Use of Cloricromene


Cloricromen (Cloricromene) is a platelet aggregation inhibitor. Cloricromen can inhibit platelet aggregation in man and in experimental thrombosis[1].

 Names

Name ethyl 2-[8-chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxochromen-7-yl]oxyacetate
Synonym More Synonyms

 Cloricromene Biological Activity

Description Cloricromen (Cloricromene) is a platelet aggregation inhibitor. Cloricromen can inhibit platelet aggregation in man and in experimental thrombosis[1].
Related Catalog
References

[1]. G Orefice, et al. No effect of cloricromen on some coagulation parameters in patients with ischaemic cerebrovascular disease. J Int Med Res. 1994 Sep-Oct;22(5):287-91.  

 Chemical & Physical Properties

Density 1.189g/cm3
Boiling Point 514.1ºC at 760mmHg
Melting Point 221-222.3ºC
Molecular Formula C20H26ClNO5
Molecular Weight 395.87700
Flash Point 264.7ºC
Exact Mass 395.15000
PSA 68.98000
LogP 3.58100
Appearance of Characters solid | white
Index of Refraction 1.532
Storage condition 2-8°C
Water Solubility DMSO: 17 mg/mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AF8970000
CHEMICAL NAME :
Acetic acid, ((8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2 H-1-benzopyran-7-yl)o xy)-, ethyl ester
CAS REGISTRY NUMBER :
68206-94-0
LAST UPDATED :
199706
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H26-Cl-N-O5
MOLECULAR WEIGHT :
395.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Blood - hemorrhage
REFERENCE :
CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,357,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,357,1991

 Safety Information

Hazard Codes Xn
Risk Phrases R22
WGK Germany 3
RTECS AF8970000

 Synonyms

MFCD06409251
Cloricromen
Cloricromenum [Latin]
Cloricromeno [Spanish]
Proendotel
Cloricromen (INN)
Cloricromene
Cloricromene [French]
8-Chlorocarbochromen
AD 6 (pharmaceutical)