20-(Tert-Butoxy)-20-Oxoicosanoic Acid

Modify Date: 2024-01-03 12:46:22

20-(Tert-Butoxy)-20-Oxoicosanoic Acid structure	Common Name	20-(Tert-Butoxy)-20-Oxoicosanoic Acid
	CAS Number	683239-16-9	Molecular Weight	398.620
	Density	0.9±0.1 g/cm3	Boiling Point	496.0±18.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₄₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	152.4±14.7 °C

Use of 20-(Tert-Butoxy)-20-Oxoicosanoic Acid

20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

Name	20-(Tert-Butoxy)-20-Oxoicosanoic Acid
Synonym	More Synonyms

Description	20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	0.9±0.1 g/cm3
Boiling Point	496.0±18.0 °C at 760 mmHg
Molecular Formula	C₂₄H₄₆O₄
Molecular Weight	398.620
Flash Point	152.4±14.7 °C
Exact Mass	398.339600
PSA	63.60000
LogP	8.87
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.463
Water Solubility	Insuluble (2.0E-4 g/L) (25 ºC)