Pendulone
Modify Date: 2024-01-07 12:38:20
Pendulone structure
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Common Name | Pendulone | ||
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| CAS Number | 69359-09-7 | Molecular Weight | 316.30534 | |
| Density | N/A | Boiling Point | 546.8±50.0 °C(Predicted) | |
| Molecular Formula | C17H16O6 | Melting Point | 221-223 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of PendulonePendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2]. |
| Name | Pendulone |
|---|
| Description | Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2]. |
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| Related Catalog | |
| In Vitro | Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC50 value 19.6 µM[1]. Pendulone displays an IC50 value of 0.43 µg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 of 1.44 µg/mL)[2]. Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC50 values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11)[2]. Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells[3]. |
| In Vivo | Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA[3]. |
| References |
| Boiling Point | 546.8±50.0 °C(Predicted) |
|---|---|
| Melting Point | 221-223 °C |
| Molecular Formula | C17H16O6 |
| Molecular Weight | 316.30534 |
| Hazard Codes | Xi |
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