Setomimycin
Modify Date: 2024-01-17 19:32:24
Setomimycin structure
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Common Name | Setomimycin | ||
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| CAS Number | 69431-87-4 | Molecular Weight | 580.58 | |
| Density | 1.479g/cm3 | Boiling Point | 841.9ºC at 760 mmHg | |
| Molecular Formula | C34H28O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 476.8ºC | |
Use of SetomimycinSetomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC50 value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity[1][2]. |
| Name | 4-acetyl-10-(1-acetyl-2,5,10-trihydroxy-2-methyl-4-oxo-1,3-dihydroanthracen-9-yl)-8,9-dihydroxy-3-methyl-4H-anthracen-1-one |
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| Synonym | More Synonyms |
| Description | Setomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC50 value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity[1][2]. |
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| Related Catalog | |
| Target |
IC50: 12.02 µM (SARS-CoV-2 Mpro)[1] |
| In Vitro | Setomimycin (0.01-1 µM) 以剂量依赖性方式抑制细胞因子 IL-1β、IL-6 和 TNF-α 的释放以及一氧化氮的释放在 LPS 刺激的 RAW 264.7 细胞中[1]。 Setomimycin (compound 1) 显示出抗菌活性，对 Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Micrococcus luteus 的 MIC 分别为 8、4、16、4 μg/mL [2]. Setomimycin (0-100 µM；5 天) 显示出抗增殖活性并抑制集落形成[2]。 Setomimycin (4, 5.5, 7 µM) 降低 p-MEK、p-ERK、Bcl-2 的蛋白表达，增加 Par-4 的表达[2]。 Cell Proliferation Assay[2] Cell Line: A549; HOP-92; Panc-1; MiaPaca-2 cells Concentration: 0-100 µM Incubation Time: 44 h Result: Showed antiproliferative activity with IC50s of 11.45, >100, 48, 4.57 µM for A549; HOP-92; Panc-1; MiaPaca-2 cells, respectively. Western Blot Analysis[2] Cell Line: MCF-7, HCT-116 cells Concentration: 4, 5.5, 7 µM Incubation Time: Result: Decreased the protein expression of p-MEK, p-ERK, Bcl-2, increased the expression of Par-4 in a dose-dependent manner. |
| In Vivo | Setomimycin (20 mg/kg；i.p.；隔天给药两周) 在小鼠体内显示出抗肿瘤活性[2]。 Animal Model: 6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2] Dosage: 20 mg/kg Administration: I.p.; every other day for two weeks Result: Decreased primary tumor weight (76%) and volume (90.5%). |
| References |
| Density | 1.479g/cm3 |
|---|---|
| Boiling Point | 841.9ºC at 760 mmHg |
| Molecular Formula | C34H28O9 |
| Molecular Weight | 580.58 |
| Flash Point | 476.8ºC |
| Exact Mass | 580.17300 |
| PSA | 169.43000 |
| LogP | 5.30760 |
| Index of Refraction | 1.73 |
| AM-2947 |
| Setomimycin |