Pivagabine
Modify Date: 2024-01-03 00:53:22
Pivagabine structure
|
Common Name | Pivagabine | ||
|---|---|---|---|---|
| CAS Number | 69542-93-4 | Molecular Weight | 187.23600 | |
| Density | 1.053g/cm3 | Boiling Point | 397ºC at 760 mmHg | |
| Molecular Formula | C9H17NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 193.9ºC | |
Use of PivagabinePivagabine (CXB 722), a psychoactive drug, is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain[1][2]. |
| Name | 4-Pivalamidobutanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Pivagabine (CXB 722), a psychoactive drug, is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain[1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions[2]. Animal Model: Adult male Sprague-Dawley CD rats (200-250 g)[2] Dosage: 200 mg/kg Administration: i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result: Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex. |
| References |
| Density | 1.053g/cm3 |
|---|---|
| Boiling Point | 397ºC at 760 mmHg |
| Molecular Formula | C9H17NO3 |
| Molecular Weight | 187.23600 |
| Flash Point | 193.9ºC |
| Exact Mass | 187.12100 |
| PSA | 69.89000 |
| LogP | 1.85380 |
| Index of Refraction | 1.462 |
| Storage condition | 2-8°C |
| 4-(2,2-dimethylpropanoylamino)butanoic acid |