Episilvestrol
Modify Date: 2024-01-11 20:43:07
Episilvestrol structure
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Common Name | Episilvestrol | ||
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| CAS Number | 697235-39-5 | Molecular Weight | 654.65800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H38O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EpisilvestrolEpisilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity. |
| Name | methyl (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1S)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate |
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| Synonym | More Synonyms |
| Description | Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity. |
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| Related Catalog | |
| Target |
eIF4A[1] |
| In Vitro | Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity[1]. Episilvestrol is cytotoxic activity against several human cancer cell lines, such as Lu1, LNCaP, MCF-7 and HUVEC cells, with ED50s of 3.8, 3.8, 5.5 and 15.3 nM, respectively[2]. The GI50s of Episilvestrol against the cell proliferation of NCI-H460 and MCF-7 cels are 17.96 nM and 17.96 nM after first test and 15.6 nM and 18.7 nM after 2 months via SRB assay. Episilvestrol also suppresses HK1 cells and EBV-positive C666.1 NPC cells[3]. |
| Cell Assay | A total of 1×104 HK1 cells/well or 3×104 C666.1 cells/well are seeded into 96-multiwell microtiter plates. At 24 h following seeding, the medium is aspirated and replaced with fresh medium containing various concentrations of silvestrol or Episilvestrol. Vehicle control cultures receive DMSO alone. The cells are then incubated for 24 h at 37°C in an atmosphere containing 5% CO2. The number of viable cells at the end of the incubation period is measured using MTS assay. Absorbance at 490 nm is read and subtracted with non-specific absorbance measured at 630 nm. Wells containing medium without cells serve as blanks. Cell viability is calculated as a percentage compared to the control cells, which are arbitrarily assigned 100% viability. The half maximal inhibitory concentration (IC50) values are graphically obtained from the dose-response curves[3]. |
| References |
| Molecular Formula | C34H38O13 |
|---|---|
| Molecular Weight | 654.65800 |
| Exact Mass | 654.23100 |
| PSA | 171.83000 |
| LogP | 1.57280 |
| Storage condition | 2-8℃ |
| 5'''-episilvestrol |
| CS-0743 |
| Episilvestrol |
| 2''-Episilvestrol |