Halofantrine
Modify Date: 2024-01-21 11:11:53
Halofantrine structure
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Common Name | Halofantrine | ||
|---|---|---|---|---|
| CAS Number | 69756-53-2 | Molecular Weight | 500.42400 | |
| Density | 1.244 g/cm3 | Boiling Point | 596.2ºC at 760 mmHg | |
| Molecular Formula | C26H30Cl2F3NO | Melting Point | 136-138ºC | |
| MSDS | N/A | Flash Point | 314.4ºC | |
Use of HalofantrineHalofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum[1]. Halofantrine blocks HERG potassium channels[2]. |
| Name | halofantrine |
|---|---|
| Synonym | More Synonyms |
| Description | Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum[1]. Halofantrine blocks HERG potassium channels[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Halofantrine blocks HERG tail currents elicited on repolarization to 760 mV from +30 mV with an IC50 of 196.9 nM[2]. Halofantrine inhibits MDA-MB-231 triple-negative breast cancer (TNBC) cell proliferation with the IC50 of 7.73±0.23 μM[3]. Halofantrine exhibits activity against asexual forms (3D7A), asexual forms (3D7HT-GFP), and mature gametocytes IV-V with IC50s of 0.0011, 0.0012, and 6.70 μM, respectively[4]. Cell Viability Assay[3] Cell Line: MDA-MB-231 TNBC Concentration: 0, 2.50, 5.00, 10.00, 20.00, 40.00, and 80.00 μM Incubation Time: 3 days Result: IC50 was 7.73±0.23 μM. |
| References |
| Density | 1.244 g/cm3 |
|---|---|
| Boiling Point | 596.2ºC at 760 mmHg |
| Melting Point | 136-138ºC |
| Molecular Formula | C26H30Cl2F3NO |
| Molecular Weight | 500.42400 |
| Flash Point | 314.4ºC |
| Exact Mass | 499.16600 |
| PSA | 23.47000 |
| LogP | 8.64430 |
| Index of Refraction | 1.577 |
| 3-DIBUTYLAMINO-1-(1,3-DICHLORO-6-TRIFLUOROMETHYL-PHENANTHREN-9-YL)-PROPAN-1-OL HCL |
| Halofan |
| 1,3-dichloro-6-trifluoromethyl-9-[1-hydroxy-3-(dibutylamino)-propyl]-phenanthrene |
| 3-(Dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-ol |