EGNHS
EGNHS structure
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Common Name | EGNHS | ||
|---|---|---|---|---|
| CAS Number | 70539-42-3 | Molecular Weight | 456.35800 | |
| Density | 1.52g/cm3 | Boiling Point | 603.4ºC at 760 mmHg | |
| Molecular Formula | C18H20N2O12 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 318.7ºC | |
Use of EGNHSEGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate |
|---|---|
| Synonym | More Synonyms |
| Description | EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.52g/cm3 |
|---|---|
| Boiling Point | 603.4ºC at 760 mmHg |
| Molecular Formula | C18H20N2O12 |
| Molecular Weight | 456.35800 |
| Flash Point | 318.7ºC |
| Exact Mass | 456.10200 |
| PSA | 179.96000 |
| Index of Refraction | 1.56 |
| InChIKey | QLHLYJHNOCILIT-UHFFFAOYSA-N |
| SMILES | O=C(CCC(=O)ON1C(=O)CCC1=O)OCCOC(=O)CCC(=O)ON1C(=O)CCC1=O |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
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| EGS |
| MFCD00049057 |
| Peg-SS |
| EGBSS |