Metixene hydrochloride hydrate

Modify Date: 2024-01-23 17:52:16

Metixene hydrochloride hydrate structure	Common Name	Metixene hydrochloride hydrate
	CAS Number	7081-40-5	Molecular Weight	363.94500
	Density	N/A	Boiling Point	419.7ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₆ClNOS	Melting Point	215-217°
	MSDS	N/A	Flash Point	N/A

Use of Metixene hydrochloride hydrate

Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1].

Name	methixene hydrochloride
Synonym	More Synonyms

Description	Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	IC50: 55 nM (mAChR)[1] Ki: 15 nM (mAChR)[1]
In Vitro	Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1].
References	[1]. Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62(2):90-4.

Boiling Point	419.7ºC at 760 mmHg
Melting Point	215-217°
Molecular Formula	C₂₀H₂₆ClNOS
Molecular Weight	363.94500
Exact Mass	363.14200
PSA	37.77000
LogP	5.69060

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

[An anticholinergic agent, the side effect of mouth dryness and hazards for the teeth].

Ned. Tijdschr. Geneeskd. 127(51) , 2318-21, (1983)

Therapeutic efficacy of R-(-)-deprenyl as adjuvant therapy in advanced parkinsonism.

J. Neural Transm. Suppl. 25 , 137-47, (1987)

To quantify the clinical benefit of an additional deprenyl administration in L-dopa pretreated patients we have performed a study of 30 patients suffering from advanced parkinsonism. During the first ...

Evaluation of an antispasmodic agent. Methixene hydrochloride (Trest).

JAMA 195(10) , 851, (1966)

Methixene hydrochloride, an anticholinergic agent, may be useful in the symptomatic treatment of functional bowel disorders. Adverse effects reported from its use are those of the anticholinergic drug...

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