206752-36-5

206752-36-5 structure

Name: Benzenecarboximidamide hydrochloride hydrate
Chemical Name: benzenecarboximidamide,hydrate,hydrochloride
CAS Number: 206752-36-5
Molecular Formula: C₇H₈N_2.ClH_.xH₂O
Molecular Weight: 174.628
Catalog: Chemical reagent Organic reagent Amide
Create Date: 2018-03-07 08:00:00
Modify Date: 2024-01-04 18:36:47
Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively[1][2].

Name	benzenecarboximidamide,hydrate,hydrochloride
Synonyms	EINECS 216-795-4 Benzenecarboximidamide hydrochloride hydrate Benzamidine HCl Hydrate MFCD00066285 Benzenecarboximidamide, hydrochloride, hydrate (1:1:1) AMIDINOBENZENE HYDROCHLORIDE Benzamidine hydrochloride, hydrate Benzamidine hydrochloride hydrate Benzamidine Hydrochloride Monohydrate Benzamidinium chloride

Description	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
Target	Ki: 20 μM (Tryptase), 21 μM (Trypsin), 97 μM (uPA), 110 μM (Factor Xa), 320 μM (Thrombin), 750 μM (tPA)[1]
References	[1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [2]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9.

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CV6260000