Prifuroline

Modify Date: 2024-01-08 15:51:20

Prifuroline Structure
Prifuroline structure
Common Name Prifuroline
CAS Number 70833-07-7 Molecular Weight 228.29000
Density 1.18g/cm3 Boiling Point 383.8ºC at 760 mmHg
Molecular Formula C14H16N2O Melting Point N/A
MSDS N/A Flash Point 185.9ºC

 Use of Prifuroline


Prifuroline is an antiarrhythmic agent.

 Names

Name prifuroline

 Prifuroline Biological Activity

Description Prifuroline is an antiarrhythmic agent.
Related Catalog
In Vivo Prifuroline is an antiarrhythmic agent. Prifuroline dose-dependently antagonizes the arrhythmogenic action of aconitine in rats, when administered either intravenously (5, 10 or 20 mg/kg) or intraduodenally (10, 20 or 50 mg/kg). Prifuroline also diminishes ventricular susceptibility to electrical stimulation in open-chest rats. The arrhythmias induced in dogs by coronary artery ligation are markedly antagonized by Prifuroline after doses of 5 and 10 mg/kg i.v. or 30 mg/kg intraduodenally. The duration of its antiarrhythmic activity in this model of arrhythmias in conscious dogs is much longer after intraduodenal than after i.v. administration[1].
References

[1]. Benharkate M, et al. Antiarrhythmic and hemodynamic effects of prifuroline. Arzneimittelforschung. 1986 Dec;36(12):1761-7.

 Chemical & Physical Properties

Density 1.18g/cm3
Boiling Point 383.8ºC at 760 mmHg
Molecular Formula C14H16N2O
Molecular Weight 228.29000
Flash Point 185.9ºC
Exact Mass 228.12600
PSA 28.74000
LogP 2.31580
Index of Refraction 1.617
Storage condition 2-8℃
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