AG 1406

Modify Date: 2024-01-12 18:26:59

AG 1406 Structure
AG 1406 structure
Common Name AG 1406
CAS Number 71308-34-4 Molecular Weight 254.32700
Density N/A Boiling Point N/A
Molecular Formula C16H18N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AG 1406


AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell[1].

 Names

Name 2-[[4-hydroxy-3,5-di(propan-2-yl)phenyl]methylidene]propanedinitrile
Synonym More Synonyms

 AG 1406 Biological Activity

Description AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell[1].
Related Catalog
References

[1]. Hui Chen, et al. Methods and compositions for inhibiting cell proliferative disorders. Patent, US5789427A.

 Chemical & Physical Properties

Molecular Formula C16H18N2O
Molecular Weight 254.32700
Exact Mass 254.14200
PSA 67.81000
LogP 4.06956
Storage condition -20℃

 Synonyms

Propanedinitrile,[[4-hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]
3,5-Diisopropyl-4-hydroxy-benzylidenmalonitril
AG 1406