CE-245677 structure
|
Common Name | CE-245677 | ||
---|---|---|---|---|
CAS Number | 717899-97-3 | Molecular Weight | 513.38 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C24H22Cl2N6O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of CE-245677CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. |
Name | CE-245677 |
---|
Description | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. |
---|---|
Related Catalog | |
In Vitro | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1]. |
In Vivo | CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1]. |
References |
Molecular Formula | C24H22Cl2N6O3 |
---|---|
Molecular Weight | 513.38 |