CE-245677

Modify Date: 2024-01-10 10:52:50

CE-245677 structure	Common Name	CE-245677
	CAS Number	717899-97-3	Molecular Weight	513.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₂Cl₂N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CE-245677

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

Name	CE-245677

Description	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Research Areas >> Cancer Research Areas >> Cardiovascular Disease
In Vitro	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].
In Vivo	CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1].
References	[1]. Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. Cancer Research. AACR Annual Meeting-Apr 14-18, 2007.

Molecular Formula	C₂₄H₂₂Cl₂N₆O₃
Molecular Weight	513.38

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CE-245677
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: CE-245677
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: CE-245677
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Get all suppliers and price by the below link:

CE-245677 suppliers

CE-245677 price