717899-97-3
717899-97-3 structure
- Name: CE-245677
- Chemical Name: CE-245677
- CAS Number: 717899-97-3
- Molecular Formula: C24H22Cl2N6O3
- Molecular Weight: 513.38
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Trk Receptor
- Create Date: 2018-08-02 01:34:22
- Modify Date: 2024-01-10 10:52:50
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CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
| Name | CE-245677 |
|---|
| Description | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. |
|---|---|
| Related Catalog | |
| In Vitro | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1]. |
| In Vivo | CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1]. |
| References |
| Molecular Formula | C24H22Cl2N6O3 |
|---|---|
| Molecular Weight | 513.38 |