Streptolydigin
Streptolydigin structure
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Common Name | Streptolydigin | ||
|---|---|---|---|---|
| CAS Number | 7229-50-7 | Molecular Weight | 600.70000 | |
| Density | 1.3 g/cm3 | Boiling Point | 826.6ºC at 760 mmHg | |
| Molecular Formula | C32H44N2O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 453.7ºC | |
Use of StreptolydiginStreptolydigin (Portamycin) is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor with a Ki of 18 μM and a Kd of 15 μM. Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases[1][2][3]. Streptolydigin possess potent antibacterial activity, particularly against anaerobes and some Gram-positive aerobes[4]. |
Summary: streptolydigin (Chinese name: 链霉溶菌素), molecular formula: C32H44N2O9, molecular weight: 600.700. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | streptolydigin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Streptolydigin (Portamycin) is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor with a Ki of 18 μM and a Kd of 15 μM. Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases[1][2][3]. Streptolydigin possess potent antibacterial activity, particularly against anaerobes and some Gram-positive aerobes[4]. |
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| Related Catalog | |
| Target |
Ki: 18 μM (Bacterial RNA polymerase)[3] Kd: 15 μM (Bacterial RNA polymerase)[3] |
| In Vitro | The antibiotic Streptolydigin (Stl) is a derivative of 3-acetyltetramic acid. Binding of Streptolydigin to RNA polymerase strictly depends on a noncatalytic magnesium ion which is likely chelated by the aspartate of the bridge helix of the active center[1]. Streptolydigin inhibits T. thermophilus RNA polymerase with a Ki of 1.8 μM[3]. Streptolydigin (Stl) inhibits initiation, elongation, and pyrophosphorolysis by bacterial RNA polymerase. Streptolydigin interacts with three structural elements within RNAP: the Stl pocket, the bridge helix, and the trigger-loop region. The Streptolydigin streptolol moiety interacts with the Streptolydigin pocket and bridge helix, and the Streptolydigin tetramic-acid moiety interacts with the trigger-loop region[3]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3 g/cm3 |
|---|---|
| Boiling Point | 826.6ºC at 760 mmHg |
| Molecular Formula | C32H44N2O9 |
| Molecular Weight | 600.70000 |
| Flash Point | 453.7ºC |
| Exact Mass | 600.30500 |
| PSA | 147.16000 |
| LogP | 2.78890 |
| Index of Refraction | 1.598 |
| InChIKey | KVTPRMVXYZKLIG-UHFFFAOYSA-N |
| SMILES | CNC(=O)C(C)C1C(=O)C(=C(O)C=CC(C)=CC(C)C2OC3(C)OC(C=CC34CO4)C2C)C(=O)N1C1CCC(O)C(C)O1 |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
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This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Antibiotic D-45 |
| portamycin |
| Streptolydigin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of streptolydigin? |
| A: InChIKey of streptolydigin is KVTPRMVXYZKLIG-UHFFFAOYSA-N. |
| Q: What is the English name of streptolydigin? |
| A: The English name of streptolydigin is streptolydigin. |
| Q: What is the LogP of streptolydigin? |
| A: LogP of streptolydigin is 2.78890. |
| Q: What is the molecular formula of streptolydigin? |
| A: Molecular formula of streptolydigin is C32H44N2O9. |
| Q: What English synonyms does streptolydigin have? |
| A: English synonyms of streptolydigin: Antibiotic D-45, portamycin, Streptolydigin. |
| Q: What is the SMILES notation of streptolydigin? |
| A: SMILES notation of streptolydigin is CNC(=O)C(C)C1C(=O)C(=C(O)C=CC(C)=CC(C)C2OC3(C)OC(C=CC34CO4)C2C)C(=O)N1C1CCC(O)C(C)O1. |
| Q: What are the uses of streptolydigin? |
| A: Main uses of streptolydigin: Streptolydigin (Portamycin) is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor with a Ki of 18 μM and a Kd of 15 μM. Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases[1][2][3]. Streptolydigin possess potent antibacterial activity, particularly against anaerobes and some Gram-positive aerobes[4]. |
| Q: What is the polar surface area (PSA) of streptolydigin? |
| A: Polar surface area (PSA) of streptolydigin is 147.16000. |
| Q: What is the molecular weight of streptolydigin? |
| A: Molecular weight of streptolydigin is 600.70000. |
| Q: What is the boiling point of streptolydigin? |
| A: Boiling point of streptolydigin is 826.6ºC at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |