N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide
Modify Date: 2024-01-16 12:21:12
![N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide Structure](https://www.chemsrc.com/caspic/359/727699-84-5.png)
N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide structure
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Common Name | N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide | ||
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| CAS Number | 727699-84-5 | Molecular Weight | 476.522 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H21FN2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamideSN-001 is a STING inhibitor with an IC50 of 3.82 μM[1]. |
| Name | N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | SN-001 is a STING inhibitor with an IC50 of 3.82 μM[1]. |
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| Related Catalog | |
| Target |
IC50: 3.82 μM (STING)[1] |
| In Vitro | SN-001 targets the cyclic dinucleotide binding pocket of human STING[1]. SN-001 (5-20 μM; 6 h) significantly impairs the induction of Ifnb mRNA, in a dose-dependent manner in L929 cells[1]. SN-001 (10 μM; 3 h) inhibits cytosolic DNA-triggered STING signaling[1]. Western Blot Analysis[1] Cell Line: L929 cells Concentration: 10 μM Incubation Time: 3 h Result: Decreased cytosolic DNA-induced phosphorylation of STING, TBK1, IRF3, IκBα, and p65, as well as nuclear translocation of IRF3 and p65. |
| Molecular Formula | C26H21FN2O4S |
|---|---|
| Molecular Weight | 476.522 |
| Exact Mass | 476.121 |
| MLS000417014 |
| N-(3-(4-fluorophenylsulfonamido)-4-methoxyphenyl)-[1,1'-biphenyl]-4-carboxamide |