N-(3-(4-氟苯基磺酰氨基)-4-甲氧基苯基)-[1,1"-联苯]-4-甲酰胺

• 常用名: N-(3-(4-氟苯基磺酰氨基)-4-甲氧基苯基)-[1,1"-联苯]-4-甲酰胺
• 英文名: N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide
• CAS号: 727699-84-5
• 分子量: 476.522
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₁FN₂O₄S
• 熔点: N/A
• 闪点: N/A

用途

SN-001是一种STING抑制剂,IC50为3.82μM[1]。

名称

• 中文名: N-(3-(4-氟苯基磺酰氨基)-4-甲氧基苯基)-[1,1"-联苯]-4-甲酰胺
• 英文名: N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide

生物活性

• 描述: SN-001是一种STING抑制剂,IC50为3.82μM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 刺
• 靶点实验:

  IC50: 3.82 μM (STING)[1]

• 体外研究: SN-001靶向人STING的环状二核苷酸结合口袋[1]。SN-001(5-20μM；6小时)以剂量依赖的方式显著削弱L929细胞中Ifnb mRNA的诱导[1]。SN-001(10μM；3小时)抑制胞浆DNA触发的STING信号[1]。Western Blot分析[1]细胞系：L929细胞浓度：10μM孵育时间：3小时结果：细胞溶质DNA诱导的STING、TBK1、IRF3、IκBα和p65磷酸化以及IRF3和p65的核易位减少。

物理化学性质

• 分子式: C₂₆H₂₁FN₂O₄S
• 分子量: 476.522
• 精确质量: 476.121
• InChIKey: DVLMVJILWFSRPS-UHFFFAOYSA-N
• SMILES: COc1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1NS(=O)(=O)c1ccc(F)cc1
• 储存条件: 2-8°C， 避光干燥

靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：qHTS of TDP-43 Inhibitors: NCGC Sytravon Library Screen 来源：NCGC External Id：tdp43-p2-repeat

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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英文别名

• MLS000417014
• N-(3-(4-fluorophenylsulfonamido)-4-methoxyphenyl)-[1,1'-biphenyl]-4-carboxamide