![]() 2-Furoyl-LIGRLO-amide (2Fly) structure
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Common Name | 2-Furoyl-LIGRLO-amide (2Fly) | ||
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CAS Number | 729589-58-6 | Molecular Weight | 777.954 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C36H63N11O8 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of 2-Furoyl-LIGRLO-amide (2Fly)2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2].. |
Name | 2-Furoyl-LIGRLO-amide |
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Synonym | More Synonyms |
Description | 2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2].. |
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Target |
Proteinase-activated receptor 2 (PAR2)[1] |
In Vitro | 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively[1]. In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Molecular Formula | C36H63N11O8 |
Molecular Weight | 777.954 |
Exact Mass | 777.486084 |
PSA | 318.75000 |
LogP | 1.17 |
Index of Refraction | 1.605 |
Storage condition | -20 °C |
N-(2-Furoyl)-L-leucyl-L-isoleucylglycyl-N-(diaminomethylene)-L-ornithyl-L-leucyl-L-ornithinamide |
L-Ornithinamide, N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-N-(diaminomethylene)-L-ornithyl-L-leucyl- |
2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist |
2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 |