EPIROPRIM

Modify Date: 2025-08-27 20:26:33

EPIROPRIM structure	Common Name	EPIROPRIM
	CAS Number	73090-70-7	Molecular Weight	353.41800
	Density	1.27g/cm3	Boiling Point	626.5ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₃N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	332.7ºC

Use of EPIROPRIM

Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci[1].

Name	5-[(3,5-diethoxy-4-pyrrol-1-ylphenyl)methyl]pyrimidine-2,4-diamine
Synonym	More Synonyms

Description	Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. H H Locher, et al. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother. 1996 Jun;40(6):1376-81.

Density	1.27g/cm3
Boiling Point	626.5ºC at 760 mmHg
Molecular Formula	C₁₉H₂₃N₅O₂
Molecular Weight	353.41800
Flash Point	332.7ºC
Exact Mass	353.18500
PSA	101.21000
LogP	3.98230
Index of Refraction	1.629
InChIKey	NMARPFMJVCXSAV-UHFFFAOYSA-N
SMILES	CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-n1cccc1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8140650

CHEMICAL NAME :: 2,4-Pyrimidinediamine, 5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-

CAS REGISTRY NUMBER :: 73090-70-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H23-N5-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1419 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

Ro 11-8958

2,4-Pyrimidinediamine,5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)

Epiroprima [INN-Spanish]

5-((3,5-Diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-2,4-pyrimidinediamine

Epiroprimum [INN-Latin]

Epiroprime [INN-French]

Epiroprim

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: EPIROPRIM
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Names

EPIROPRIM Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.