EPIROPRIM

Modify Date: 2024-03-04 08:28:18

EPIROPRIM structure	Common Name	EPIROPRIM
	CAS Number	73090-70-7	Molecular Weight	353.41800
	Density	1.27g/cm3	Boiling Point	626.5ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₃N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	332.7ºC

Use of EPIROPRIM

Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci[1].

Name	5-[(3,5-diethoxy-4-pyrrol-1-ylphenyl)methyl]pyrimidine-2,4-diamine
Synonym	More Synonyms

Description	Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. H H Locher, et al. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother. 1996 Jun;40(6):1376-81.

Density	1.27g/cm3
Boiling Point	626.5ºC at 760 mmHg
Molecular Formula	C₁₉H₂₃N₅O₂
Molecular Weight	353.41800
Flash Point	332.7ºC
Exact Mass	353.18500
PSA	101.21000
LogP	3.98230
Index of Refraction	1.629

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8140650

CHEMICAL NAME :: 2,4-Pyrimidinediamine, 5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-

CAS REGISTRY NUMBER :: 73090-70-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H23-N5-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1419 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

Ro 11-8958

2,4-Pyrimidinediamine,5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)

Epiroprima [INN-Spanish]

5-((3,5-Diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-2,4-pyrimidinediamine

Epiroprimum [INN-Latin]

Epiroprime [INN-French]

Epiroprim

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: EPIROPRIM
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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EPIROPRIM

Use of EPIROPRIM

Names

EPIROPRIM Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms