依匹普林

• 常用名: 依匹普林
• 英文名: EPIROPRIM
• CAS号: 73090-70-7
• 分子量: 353.41800
• 密度: 1.27g/cm3
• 沸点: 626.5ºC at 760 mmHg
• 分子式: C₁₉H₂₃N₅O₂
• 熔点: N/A
• 闪点: 332.7ºC

依匹普林用途

Epiroprim (Ro11-8958) 是一种选择性二氢叶酸还原酶 (DHFR) 抑制剂。Epiroprim 对葡萄球菌、肠球菌、肺炎球菌和链球菌表现出优异的活性。

依匹普林名称

• 中文名: 依匹普林
• 英文名: 5-[(3,5-diethoxy-4-pyrrol-1-ylphenyl)methyl]pyrimidine-2,4-diamine

依匹普林生物活性

• 描述: Epiroprim (Ro11-8958) 是一种选择性二氢叶酸还原酶 (DHFR) 抑制剂。Epiroprim 对葡萄球菌、肠球菌、肺炎球菌和链球菌表现出优异的活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. H H Locher, et al. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother. 1996 Jun;40(6):1376-81.

依匹普林物理化学性质

• 密度: 1.27g/cm3
• 沸点: 626.5ºC at 760 mmHg
• 分子式: C₁₉H₂₃N₅O₂
• 分子量: 353.41800
• 闪点: 332.7ºC
• 精确质量: 353.18500
• PSA: 101.21000
• LogP: 3.98230
• InChIKey: NMARPFMJVCXSAV-UHFFFAOYSA-N
• SMILES: CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-n1cccc1
• 折射率: 1.629

依匹普林毒性和生态

依匹普林靶点实验

查看更多实验

实验名称：In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase. 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL665036

实验名称：Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by ... 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL668845

实验名称：Inhibition of chicken liver dihydrofolate reductase 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL664359

实验名称：Selective index against Pneumocystis carinii versus rat DHFR 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL665044

实验名称：Inhibition of Dihydrofolate Reductase of Pneumocystis carinii. 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL664180

实验名称：Inhibitory activity against chicken liver dihydrofolate reductase 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL661844

实验名称：Selectivity index was determined by the ratio for IC50 of rat liver DHFR to the IC50 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL850491

实验名称：Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was eva... 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL664185

实验名称：Inhibition of Pneumocystis carinii Dihydrofolate Reductase 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL664375

实验名称：Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 uM dihyd... 来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase External Id：CHEMBL665616

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依匹普林英文别名

• Ro 11-8958
• 2,4-Pyrimidinediamine,5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)
• Epiroprima [INN-Spanish]
• 5-((3,5-Diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-2,4-pyrimidinediamine
• Epiroprimum [INN-Latin]
• Epiroprime [INN-French]
• Epiroprim